Watson (2024) s02e10 Episode Script
Never Been CRISPR'd
1
JENNA: I don't get it.
Glowing chest what does that mean?
It's not a riddle.
I have a glowing chest.
(LAUGHS) Um, those two words
don't belong together.
Chests don't glow.
But they can glow.
See, I gave myself
a treatment called CRISPR.
CRISPR: "Clustered
regularly interspaced
short palindromic repeats."
It hacks your DNA. Changes your genes.
You can make your body different.
You can make it better.
You can make it glow.
Why, though?
Glowing chest.
There is a longer answer.
Um, divorce, general lack of purpose.
The human need
to pursue something, anything,
even a glowing chest.
Especially a glowing chest.
Are you lying?
Glowing chest.
Um,
there was someone in here earlier,
had a fork stuck to her fingers.
Neodymium magnetic implants.
Um, technically,
it's a body mod, not a gene hack,
but we're all
part of the same community.
And is that legal?
The law is
still catching up to what we do.
WENDY: Hobie?
Wendy. Hi.
- Hi.
- Um
Oh.
Sorry, that was
- Um
- Okay. (CHUCKLES)
It's so nice
to meet you in person. Um,
you look exactly like you do on chat.
You look better.
Um, do-do you want to sit?
I got us a table.
Yeah, we could.
Or, um
we could get room service.
(LOCK BEEPS)
(EXHALES SHARPLY)
You went all out.
What if you weren't attracted to me?
I wasn't worried.
Hobie McSorley from Pittsburgh.
Wendy Goss from Utica.
Are you sure you want to do this?
I mean, body mods are one thing.
We're talking about
getting into your genome.
I'm sure.
I want my first time to be with you.
Okay, this might be weird,
and it's definitely too soon,
- but
- Mm-hmm.
I think I want to say "I love you."
Well, it's not any weirder
than what we're about to do.
I love you too, Hobie.
Put it in me.
♪
(GASPS) It's working.
(LAUGHS)
Yours should appear any second.
Okay.
Hmm.
Maybe we should kiss.
- Yeah.
- Yeah.
Yeah.
(GASPS)
I'm sorry, Hobie.
I don't feel so great.
- What?
- Um
- You okay?
- No.
- Wendy?
- Um
♪
(SHINWELL CLEARS THROAT)
Sorry to interrupt.
It's the end of the day, Shinwell.
I think, at the end of the day
- I am aware of this.
- Ten minutes.
Ten minutes to review our cases
and think about next steps.
It's not an enormous ask.
No, it's it's an entirely
reasonable ask.
But I do wonder if, perhaps,
on this particular evening,
your ten minutes
can perhaps wait ten minutes?
It's the fellows.
They're struggling a bit
with the transplant.
WATSON: Okay, first, somebody's
gonna have to pick up the snot
and put it in the fridge.
Snot transplant.
- I don't like it. Sounds fake.
- It's real.
We're doing it tomorrow.
Remind me how we picked the donor.
By the quality of her snot, obviously.
Which is measured how?
Okay, enough.
Laine Sudow has had sinus
infections her entire life.
Tomorrow, we swap out her
bad snot for the good snot.
Problem solved.
But first, someone
has to preserve the specimen.
Y'all are such wimps.
(GROANS)
Thank you, Dr. Lubbock.
Where are you going?
To think.
John, you're still here. Good.
My body's still here.
My brain is looking
for someplace way far away.
I was going to ask you for a favor,
but if you're in your
special selfish genius place,
- it can wait.
- I don't have a special
selfish genius place.
What is it?
I won an award.
The Deltas are honoring me
for my work in the clinics.
I say a few words, I get a plaque,
my picture goes on the wall.
Wow, the Deltas.
That's huge. Congratulations.
Someone has to introduce me.
They talk about my work,
my volunteer commitments,
my good qualities.
Someone
Do I need to fill in the blanks?
Oh, so you want me
to give a speech about you.
About my professional
and philanthropic achievements.
You can leave the other stuff out.
I'm gonna ask Dr. Kim.
Okay, no, look, I will do it.
Of course I'll do it.
Give me the time, place
and the dress code,
and I'll be there.
Thank you.
Oh, John, I have to submit
the introduction ahead of time.
Two minutes or so.
Get it to me two days from now?
You got it.
♪
(MAN MOANING)
Sherlock?
Watson.
I was hoping to surprise you.
You've been sleeping
in the abandoned wing?
Just the past couple nights.
We've had worse, my friend.
Yeah, but why?
Ah.
It's under there, Watson.
(PHONE VIBRATES)
Awaiting the grand unveiling.
What's under there?
In 1929, the markets crashed.
The prairies turned to dust
and your country starved.
I know about the Great Depression.
And did you know that your government,
in an effort to keep people working,
commissioned a series of public murals
by the great artists of the day?
Some are as good as new.
Others have been lost.
That wall, John.
A mural by the late Charles Alston
under the paint there.
Looks like a wall, Holmes.
Well, you have to look deeper, Watson.
It's a miracle.
A masterpiece,
- waiting to be uncovered.
- (PHONE VIBRATES)
Holmes.
You have to look deeper, Watson.
It's a miracle.
A masterpiece,
waiting to be uncovered.
You just said that.
Did I? I don't think so.
No, yeah, you did.
Look, whatever this is,
let's go back to my place
and talk about it, okay?
(PHONE VIBRATES)
Hobie, I'm a little busy right now.
John, I need your help, John.
I need your help now!
What's going on?
It's Wendy. She's my, uh
I don't know, I don't know. We were
we were doing a CRISPR mod together,
and I was careful.
I promise I was so careful.
Calm down. Tell me what happened.
I love her.
I mean, I think I love her.
I told her I love her.
I'm in love with Wendy, Watson.
And I'm worried maybe I killed her.
♪
- (INDISTINCT RADIO CHATTER)
- ♪
♪
NURSE: Incoming. Room 3 is empty.
Wendy. Wendy, I'm Dr. Marcus.
Can you hear me?
Wendy Goss. Are you with us, Wendy?
Oh. You warned me.
You warned me over and over again.
Send a stat CBC and a chem 7.
You told me that
if I kept playing with DNA,
something bad
was gonna happen, but I thought
you meant me, you know?
I didn't care about myself.
I mean, not then, anyhow.
Okay, Hobie, you can
beat yourself up later.
I need to know what you two were doing
in that hotel room.
It was the first time
that we met in person,
and we wanted to make it special,
so I-I worked up a love mod.
What's a love mod?
It's a riff on the biohack
I used to make my chest glow,
except using bioluminescence
from red mushroom coral.
Me and Wendy
we were supposed to get
matching glowing hearts,
but only when we were together
and, you know, feeling
love.
You just met tonight.
How could you be in love?
Forget that.
We'll talk about that later.
So, if I'm hearing you right,
this glow
it's triggered by oxytocin.
The love hormone.
Okay, what about the heart shape?
They're tattoos, just using
my gene cassette instead of ink.
I-I mailed Wendy the serum so that
we could get tattooed
in time for her visit.
The injection at the hotel
it was just a booster.
It-it was Wendy's
first time messing with CRISPR.
She trusted me, Watson.
I know. Yeah, I know she did. Listen,
Wendy is my patient now.
We're gonna do everything we can
to bail you out of this.
I need a sample of the serum,
the booster,
your whole full schematic.
Wait, bail me out? What do you mean?
- Am I-am I in trouble?
- Your girlfriend is sick, Hobie.
You injected her with something
you cooked up in your garage,
and she's sick.
Now, are you in trouble? I don't know.
If we can't make her better
I don't know.
Wendy Goss. She's in the ICU
now with hemolytic anemia.
Her red blood cells
are popping like balloons.
So far, her kidneys are unaffected.
Let's focus on finding the cause.
It's the tattoo.
Innit?
In my observations,
I have observed
that a couple's tattoo
is the surest path to suffering.
I didn't mean the karma cause.
I was looking for the medical cause.
STEPHENS: Could be infection.
Her body mods put her at higher risk.
Or an immune-driven food allergy.
Okay, good. Good.
Let's test her antibody level
and start antibiotics.
Sorry, this woman mainlined
a garage juice CRISPR cocktail,
and we're worried about allergies?
We need to consider
everything, Dr. Derian,
but that is a fair point.
Wendy is a biohacker.
She's been experimenting with
mechanical additions and implants.
Hobie's love mod is the first time
she messed with her own genome.
So this could be genetic instability.
The labs are gonna tell us more,
but for now,
let's explore if Wendy's issues
come from her body mods
or Hobie's shot.
Sasha and Stephens,
hit the lab.
Check the serum and Wendy's DNA,
especially the sequence
that was targeted by that mod.
Ingrid and Adam, go to Wendy's hotel,
dig through all of her stuff.
See what else we can learn
about these mods.
Dr. Watson,
did you, by chance,
invite the Pittsburgh Police
this evening?
Detective Lestrade.
To what do I owe the pleasure?
Evening, good looking.
How do you keep your suit
so perky after sundown?
Maybe I sweat starch.
Maybe I don't sweat at all.
- How can I be of service?
- Not here to see you.
I need a word with Dr. Lubbock.
Me? Is everything okay?
Is there a private place
we could talk?
SASHA: He's dead?
Uncle Jun is dead?
A neighbor called in a wellness check.
We found him lying in bed.
There were a couple of
beer cans scattered around.
I recognized a photograph
of you on the nightstand.
You called him Uncle Jun?
What was the nature
of your relationship?
It's just how he introduced himself.
He said he was my uncle.
He said that,
uh, he knew my birth mom.
But the whole approach was a lie.
He was just looking for someone
to talk to.
What happened to him?
We don't know yet.
There were certain signs.
You think he did this to himself?
We have to wait for
the toxicology report
to get back, but,
uh, there's a gray area between
doing it to yourself
and letting it happen.
We call that a death of despair.
This kind of feels like that.
You hadn't spoken to Jun recently?
Not for a while. Uh,
not since I figured out
he was lying to me.
He died alone?
I'm afraid he did.
It's a sad situation, but this
is not your fault, Dr. Lubbock.
If you're interested, I could
let you know what I learn.
Uh
This is a hospital room, not a crypt.
Well, I'm trying to make up
for the fact that
our first date ended up in the ICU.
Hobie, you told the triage nurse
that Wendy had an RFID chip
made of bioglass
in the back of each hand.
We haven't seen
any sign of infection there.
Are there any other body mods
that we should know about?
The finger magnets. And she has
a transmitter in her ribcage.
Wendy told me
that it was supposed
to send her body temperature
to her thermostat.
There were complications.
Okay, so we'll test
for metal toxicity.
We'll also measure
her cytokine levels.
Okay.
She's jaundiced.
Looks like her anemia's getting worse.
Half my team
is looking over her labs,
the other half
is digging through that hotel room.
We'll know something soon.
- Okay.
- But Hobie,
why did you do this?
Love.
I wish you'd stop saying that.
You can't love someone
you met five hours ago.
You disagree?
I disagree because you're wrong.
Judge what
we did, what I did, but
don't tell me who I can love.
You're not that good of a doctor.
(DOOR CLOSES)
It looks like a Hallmark card
threw up in here.
No visible signs
of mold or pesticides.
I'll check for moisture.
You want to check the fridge?
You okay?
Ingrid, you're staring.
Nothing's gonna, um
happen here. You realize that, right?
Happen? Ew. What could possibly
make you think
that something might happen?
We're in a hotel room
and you're staring at me.
I'm not staring at you,
I'm judging you.
I'm deciding if
I want to tell you something.
Oh. Okay.
What is it?
I'm in the middle of a situation
that might not be so great.
I can't talk to anybody about it
because they'd have opinions.
You're kind of a blank slate
human void, if you will
so you might be safe.
That is so sweet.
Remember Beck? Beck Wythe,
like "lithe" but with a "W"?
You mean the guy who stabbed
a man in the neck
with a pair of scissors
right by my desk?
I do remember him. Yes.
I go over
to his place sometimes.
We take off our clothes.
That kind of thing.
And are you asking me
if you should stop?
Because you should definitely stop.
(SCOFFS) I know what Beck is.
In fact, I hold him in contempt.
But there is one specific thing
that he's very good at.
In my head, there are compartments.
And in one drawer
is who Beck is,
in the other drawer is what Beck does.
They're the same drawer.
Sasha guessed it.
I told her I'd stop.
- I do feel bad about that.
- (SHORT CHUCKLE)
You've come a long way.
Not nearly far enough, but still.
I'll break this down for you.
There's you.
You're a mess.
Dangerous at times,
but still, you know, Ingrid.
And over here,
there's Beck.
And he is something
different altogether.
I don't care if you guys
go to the same therapy group
or if you have the same
diagnosis or whatever.
I was locked in a room
with a man strapped to a bomb
and with Beck.
Beck scared me more.
End this.
Don't overestimate yourself.
Huh.
She has chikke'en in her fridge.
Didn't Hobie say that Wendy was vegan?
No, not chicken.
Chikke'en with two Ks.
Does it make a difference?
I don't know.
I'm gonna text Watson the ingredients.
(HOLMES MUTTERING)
Sherlock.
(HOLMES STAMMERS)
Ah.
Were you watching me?
What's going on with you, Holmes?
I don't just mean
the camping out at the hospital.
I mean the faking your own death,
disappearing acts, the paranoia.
Spray-painting
the walls at my hospital.
What's going on?
I've been thinking about dying, John.
I'll be gone
soon enough.
We'll all be gone soon enough.
But right now,
today, here, on your couch,
my mind still works.
Now, look, I could solve crimes
until I keel over, and I'm not saying
that's time wasted.
But what is true
is that the very moment
the exact, literal
moment of my death
someone somewhere
will murder somebody else,
and I haven't really
changed anything, have I?
I haven't left anything behind.
You've helped people, Holmes.
You've given families justice,
peace of mind.
Is that what I owe the world forever?
A finger in the dam
until the day I die?
I want my choices to outlive me.
I know that sounds vain.
But if I can be just a bit kinder.
If things can be a bit more fair.
If I can show people something
something beautiful
that's been covered
under paint for decades,
that's something, isn't it?
"Sherlock Holmes was here."
The older I get,
the louder I want
to shout that into the void.
Stupid.
You don't have
a cuffed shirt on, Holmes.
Your left hand you're plucking away
at your right wrist,
same as you did yesterday.
You're concerned about my behavior.
I wouldn't call it behavior.
It's more like symptoms.
No symptoms, John.
- (PHONE VIBRATING)
- My priorities are shifting.
Isn't that what friends do?
Stand beside each other
through life's changes?
Hobie.
She's peeing blood, Watson.
Calm down, Hobie.
Wendy slept through the night.
She seemed maybe,
I don't know, like,
a-a little bit better?
And then she
started crying in the bathroom.
She's peeing blood.
Okay, don't panic.
Okay, this could be anything.
Could be benign.
And there's no doctor here.
We keep asking for a doctor.
Okay, I'll be right there.
Just stay calm
and help Wendy stay calm.
Okay.
HOLMES:
Not to call you out, my friend,
but whatever that is,
it doesn't seem like
you believe it's benign.
I think my patient's kidneys
are failing.
My kidneys are failing?
You have hemolytic anemia.
We're hydrating you
as aggressively as we can.
That should help protect
your kidney function.
You will be here
for a little while, Wendy.
Is there anyone you'd like us to call
or anyone you think should travel?
Um, I should call Parker.
She's the other paralegal
in my department. She
she's watching my cats.
I'll do it.
It'll be fine, I promise.
- Okay. Thank you.
- Yeah.
Anyone else?
Do you have someone, Dr. Watson?
Yeah, I do.
You should go to her right now.
Him, her, whatever.
Wrap your arms around her.
Time gets short really fast.
It's Laila. She's traveling.
But there is an underlying
cause to this, Wendy.
You and Hobie took
the same CRISPR treatment.
There's a reason why
it's affecting you and not him.
If we can figure that out,
then we can get you better.
I hope that happens.
Last night things seemed really good
for the first time in a long time.
But if something happens, if I
go on dialysis, if I can't talk?
I consented.
I knew everything about CRISPR.
I understood the risks.
I did it because I wanted to do it.
(SIGHS)
You have to tell people that, okay?
You have to tell them
it wasn't Hobie's fault.
Wendy Goss did not have a good night.
I don't know how many more
bad nights she has in her.
Who's got something for me?
Adam and I came back to Point House
to talk to employees
who weren't here last night.
Wendy asked a desk clerk
to send up loperamide.
She was worried she got food poisoning
from a french fry sandwich.
GI symptoms, huh?
We were thinking
hemolytic uremic syndrome
caused by a shigella infection.
She's already on antibiotics.
If it were bacterial, her
symptoms should be improving.
Remind him about
the chikke'en with two Ks.
Adam asked me to remind you
about the chikke'en with two Ks.
I'm aware of the fake chicken.
If it becomes relevant,
I'll let him know.
We're double-checking Wendy's samples.
The sequencer shows
clean serum, clear targets.
Sasha's working on a karyotype.
And she's okay?
She seems fine.
She's been quiet.
You sure about that?
A man died yesterday
with Sasha's picture
on his nightstand.
She keeps saying she's fine.
She wants to work.
WATSON: All right, Stephens,
let us know what comes back.
Ingrid, tell Adam
to stick around the hotel.
We should interview
every staffer who talked to Wendy.
INGRID:
Sure. Am I not doing that, too?
You're coming back to UHOP.
I need to see you in my office.
Wait, am I in trouble?
Hey.
I am still making that list
of all your good qualities.
Might take a minute.
Actually, I heard back from Dr. Kim.
She was on vacation with her family.
Turns out she can do it, so
Wait, hold up. Hold up.
So I was your backup choice?
You're busy, John. You're always busy.
Dr. Kim is my mentor.
Wow, so I was your fallback, huh?
(SCOFFS)
Consider yourself off the hook.
Look, I appreciate it.
I really do.
All right, wait. Hold up.
I want to do it.
Okay? Look,
I'm not gonna force my way in,
but, yeah, I want to do it.
So I tell you what.
If you asked Dr. Kim
because you think that
she'll give a better speech,
I'll bow out.
But if you think I'm too busy
or I might blow it off,
I'm not and I won't.
If you want the John Watson Special,
I will be there and I will deliver
the John Watson Special.
You good?
Yep, I should have Wendy's
karyotype ready in a second.
No, I mean, um
are you good?
That was awful.
That man Uncle Jun or
(SCOFFS)
whatever we're supposed
to call him now.
That was terrible news.
You were kind to him.
Even after you found out he was
scamming you, you were still kind.
I don't know if he was scamming me.
He didn't ask for money. He
just wanted someone in his life.
I feel sorry for the man,
but how you treated him?
It was better than
he had any right to expect.
Who do you think he was?
How did he get
that baby picture of you?
Before he came here, he worked
for the Chinese government.
There are layers at these
international adoption agencies.
Jun worked for one of them.
- You never told me that.
- I didn't know.
If it's even true, I didn't
know until this morning.
Stephens, I got an email.
A-Apparently, before he died,
however he died,
Jun passed
my contact information along.
Passed it to who?
Read it for yourself.
"Dear Sasha, my name is Shu-Yi."
Oh, my God.
Is this real?
I don't know yet, but if it is,
I just got a message
from my birth mom.
What do you want me to say here?
I want your opinion.
I have this friend who has
been behaving differently.
It's little thing, big things.
It all adds up
to a pattern I'd call erratic.
I'm concerned.
Well, you're right to be worried.
These little blank moments
in the middle of a conversation,
they could be
complex partial seizures.
There's no history
- of epilepsy?
- No.
The repetitive movements,
they also don't sound good.
We call it "meaningless reaching."
But you are John Watson.
You know all this.
But I'm not sure
that I can be objective here.
Tell me tell me
what you see, Dr. Derian.
This friend of yours, whoever he is,
he's displaying symptoms
that could represent a brain tumor.
He could be very sick.
Your friend needs to come see me.
Today.
(KNOCK AT DOOR)
STEPHENS: Watson,
we just finished
Wendy Goss's karyotype.
You need to see this.
The karyotype on the left
is from a healthy human female.
The chromosomes
on the right are Wendy's.
Look at this.
INGRID: What is this?
Half of Wendy's
X chromosomes are shattered.
It's definitely not chemical exposure.
We would have seen it
on the comet assay.
Could it be a virus?
Shiga toxin, maybe?
No, it's too clean.
Viral damage is messy.
SASHA: It can't be the love mod.
She just got that yesterday.
It's not Hobie's mod,
but it definitely looks
like CRISPR damage to me.
It's the only thing
that could have shredded
her chromosomes like this.
The love mod was the first time
Wendy edited her genes.
That's what she told us.
She was lying.
Wendy's used CRISPR before.
She did it so often
or was so sloppy with it,
she wrecked her own chromosomes.
There's so much damage.
We may not be able to help her.
I'm sorry. I should have told you
I hacked my genes before.
Hobie was here. I'm sorry.
I don't follow.
Hobie plays with his DNA
like a Rubik's Cube.
Why would he care?
I kind of left it out at first.
Then the more we talked,
the more excited he got
about me doing my first mod with him.
It was a new thing.
I wanted it to become a real thing.
I let Hobie believe
what he wanted to believe.
About a year ago,
I placed three
extra olfactory subvariants
in my OR3A subfamily.
You enhanced your sense of smell?
I have cats. They have
200 million scent receptors.
I wanted to
I don't know, see what
the world is like for them.
It's stupid.
Are you gonna tell Hobie I lied?
No, no, that's your job,
if you want to do it.
My job is to figure out
why CRISPR damage from
a year ago has you in the ICU.
I sent him home to get some sleep.
I'll just send him an email.
If he doesn't want to come
back here, he doesn't have to.
(KNOCK ON DOOR)
Watson, I just
got back from the hotel.
I heard about the karyotype.
The chikke'en with two Ks
Yes, yes, I'm aware of the chikke'en,
and I'm aware of the two Ks.
The protein in there,
they make it with fava beans.
Does that matter?
The humble fava bean.
It can trigger extreme
hemolytic anemia
like Wendy's but only when
a patient suffers from
A G6PD deficiency.
When Wendy took those passes
with CRISPR,
she triggered a mutation in this gene.
- You knew this?
- Mm-hmm.
- You've come a long way.
- Thank you?
Not nearly far enough, but still.
Wendy hasn't had fava beans
since she was admitted here.
Shouldn't the transfusions
have made a difference by now?
The antibiotics.
We've been trying
to stave off infection.
99% of the time,
that's the right move.
But with this mutation,
it actually makes things worse.
We can help her.
We can do better than that.
Wendy's chromosomes
will be damaged forever,
but she can live.
We'll adjust her medications,
and hopefully,
with one last transfusion,
she'll be back on her feet.
She can lead a full life,
but only if she avoids
a few medications
- and
- Fava beans.
Fava beans.
Adam and Ingrid,
monitor Wendy's progress.
Sasha and Stephens, dig into
the backlog of our remote consults.
We should be wrapped up here soon.
You okay?
Can I show you something?
STEPHENS: Wow.
You're really gonna send this?
I think I am.
It's not crazy that she reached out.
Jun wasn't my uncle, but he did have
a connection to my family.
I believe that he felt guilty
for what he did
and passed along my information
before he died.
Look, if it's something else,
if she asks for money
or if it's a scam,
I'll never respond again.
I guess I just don't see a downside.
I don't know.
Disappointment, I guess.
What do I have to be disappointed for?
I'm living every dream I ever had.
I have a family already.
They can be
annoying as hell sometimes,
but they ain't going anywhere.
(STEPHENS CHUCKLES)
I have you.
I'm gonna be fine.
Whatever comes back,
I'm going to be great.
WATSON: I knew I'd find you here.
Well, I'm always happiest
when I'm working.
You know that.
You don't believe me, do you?
You don't believe it's under there.
- I don't think it matters.
- (LAUGHS SOFTLY)
You're a genius, Sherlock.
I would never question that.
But I'm
not thinking about
what's under that paint.
Remember Alexander Petrov?
The Cobalt Fissure?
A three-day pursuit
chasing our quarry
across the Russian steppe?
How could I forget that?
Yeah, it was a three-day pursuit
that ended with us
surrounded by soldiers
in biohazard gear.
I think about it all the time.
It was three days.
Three days exposed to,
to God knows what.
I think you're sick, Sherlock.
I think there's something
growing inside you.
Everything that you've been doing
the faking your own death,
the paranoia,
the secrecy you're not yourself.
It hasn't been easy, John.
I'm Sherlock Holmes.
I know exactly how to solve a problem.
I'm not afraid of a mystery.
I'm not afraid of anything.
It hasn't been easy.
So come on into the hospital.
I will keep it as quiet as I can,
but you need to see a neurologist.
Forgive me if I'm nervous.
It's been a while
since I've felt this exposed.
WATSON: It's right here. This room.
So, wait here,
and I'll go get Dr. Derian.
ADAM: Your numbers
are looking good, Wendy.
Transfusions are working.
You don't seem happy.
I haven't heard back from Hobie
so I guess we're done.
Okay, so you maybe lost
a potential boyfriend.
Bummer. But you're gonna live.
(DOOR OPENS)
Scent receptors?
- Cats?
- I'm sorry, Hobie.
Did you think I would care
about any of that?
Did you think
I would care for one second?
INGRID: We'll give you two a minute.
Oh, my God, Hobie, it's working.
(LAUGHS)
I thought about what you said.
I'm gonna end it with Beck.
I think that's a good idea.
I appreciate you taking my advice.
I thought about what you said.
And when you get down to it,
penises abound.
(CHUCKLES)
Yeah, I guess they do.
And you have to sort through
a pile to find the one
that does what it's supposed to,
but penises abound.
(FOOTSTEPS APPROACHING)
Watson?
- Everything okay?
- HOBIE: I need your help.
- I need your help.
- (ALARMS SOUNDING)
I kissed her.
A-All I did was kiss her.
We need some help in here.
What is happening?
Let's get her on some oxygen.
What happened?
What-what-what did I do?
What did I do?
- What happened, Hobie?
- I already told you.
- I kissed her. That's it.
- The tattoo on Wendy's forearm.
It glowed. It didn't before,
but right before you kissed, it did.
HOBIE: Does that matter?
I thought that just meant
she didn't love me until now.
Watson.
Does that matter?
Wendy's inflammation inhibited
her flow of oxytocin.
When we stopped triggering her
with antibiotics,
her love hormone could flow freely.
ADAM: That explains the glowing,
but what's wrong with her?
I think we have uncovered
a new allergy.
We're gonna be fine.
Wendy's gonna stabilize,
we'll reverse her love mod
and she's-she's gonna be fine.
(EXHALES): Okay.
If Wendy's gonna be fine,
then why do you look so sad?
We fixed Wendy's response
to the fake chicken
with the fava beans.
Now that her oxytocin's
flowing freely,
she's having a reaction
to the tattoo's
bioluminescence proteins.
Like I said, we have to reverse
the love mod that you gave her.
Great.
I how is that not great?
Your chest, Hobie.
You. You're filled
with the same proteins.
Wendy's not just allergic
to the tattoos.
She's allergic to you.
You can't be around her.
You will kill her.
So, reverse it. Take away my glow.
- Who cares?
- You know I can't do that.
You've been playing God
with your own genome for years.
I mean, to walk all that back
The number of genes
that we'd have to open up
There's no map.
You'd experience
genomic instability
off-target mutations.
You'd probably die.
I'm not gonna help you do that.
INGRID: Watson.
We've got her stable.
WATSON: I'm sorry, Hobie.
Wendy's gonna live. You're gonna live.
You just can't be together.
(EXHALES)
SHINWELL: You wanted to see me, guv?
He's alive, Shinwell.
Holmes. He's alive.
Wow.
"The Pittsburgh Mystery."
Holmes mentioned this.
I was meant to keep it secret.
I've had me suspicions, guv.
Ever since you first used that phrase,
- I've had me suspicions.
- No.
Holmes is sick.
I think he's very, very sick.
We have to find him, Shinwell.
("LONELY IS THE NIGHT"
BY BILLY SQUIER PLAYING)
- Hobie.
- Hey.
What are you doing?
You can't be here, Hobie.
Maybe not yesterday, but today
I'm right where I need to be.
Wendy, can I show you something?
Just give me 30 seconds,
and if you want me to go,
I'll go.
STEPHENS: You did it to yourself.
- You've reversed your mods.
- WATSON: What's the matter
with you, Hobie? You could have died.
- You still could.
- WENDY: Why?
Why would you do that?
You're the Man with the Glowing Chest.
No. That's not true.
The only reason I ever glowed
was so that you could find me.
♪
You are here now.
The technology's obsolete.
Hobie.
MARY: I know things
got crazy here today.
I'm letting you off the hook.
I wrote it.
I told you I was gonna do it,
so I did it.
Thank you.
(INDISTINCT CHATTER)
INGRID: This isn't a good idea.
- Hi.
- Don't interrupt.
This isn't a good idea.
You're not a good idea.
Okay.
"Okay"?
We're two bad people, Ingrid.
Two bad people doing
a good thing for each other.
But if it's not working
for you anymore
I get it. I'm good.
If you change your mind,
that's okay, too.
You know where to find me.
(LAUGHS SOFTLY)
I expected
I don't know,
a-a fight, a scene. Something.
(LAUGHS SOFTLY)
It's okay.
Well, therapy is about to start.
Yeah, I'll be in in a few.
I just got to finish this.
♪
I can't believe it,
and you're incredibly lucky,
but you're doing just fine.
That was really stupid, by the way.
I know that.
Of course I know that.
(SIGHS)
Your girlfriend. Laila, right?
- Is she back in town?
- Yeah, I saw her last night.
HOBIE: And yet something tells me
you still haven't done the deed.
We're grown-ups, Hobie.
Of course we've done the deed.
No, I'm not talking about sex.
Have you told your girlfriend
that you love her yet?
Again, we're grown-ups.
We're doing things at a grown-up pace.
(SIGHS) You're a
smart man, John Watson,
so I'm sorry for saying this, but
you can be a real idiot sometimes.
- Life is hard.
- Hmm.
It's hard and it's confusing
and it's lonely.
And we all live in the middle
of that, and sometimes
we are lucky enough
to find someone to love.
To have someone
who might love us back.
And if you've got that,
it's not time to be smart.
It's not time to be a grown-up.
If you're not willing to lay
yourself on the line for love,
if you're not willing to be stupid,
then why do you even
deserve love in the first place?
Now, I'm glad I am doing better
but I think you should go now
and find the woman you love,
and I think you should
tell her all about it.
Lonely is the night ♪
When you find yourself alone ♪
Your demons come to light ♪
And your mind is not your own ♪
- Hey, is she in?
- Conference room, but she's in a meeting.
Sorry, this can't wait anymore.
- And it's a high time to ♪
- Mary.
MARY: John. What are you doing?
sync & corrections awaqeded
JENNA: I don't get it.
Glowing chest what does that mean?
It's not a riddle.
I have a glowing chest.
(LAUGHS) Um, those two words
don't belong together.
Chests don't glow.
But they can glow.
See, I gave myself
a treatment called CRISPR.
CRISPR: "Clustered
regularly interspaced
short palindromic repeats."
It hacks your DNA. Changes your genes.
You can make your body different.
You can make it better.
You can make it glow.
Why, though?
Glowing chest.
There is a longer answer.
Um, divorce, general lack of purpose.
The human need
to pursue something, anything,
even a glowing chest.
Especially a glowing chest.
Are you lying?
Glowing chest.
Um,
there was someone in here earlier,
had a fork stuck to her fingers.
Neodymium magnetic implants.
Um, technically,
it's a body mod, not a gene hack,
but we're all
part of the same community.
And is that legal?
The law is
still catching up to what we do.
WENDY: Hobie?
Wendy. Hi.
- Hi.
- Um
Oh.
Sorry, that was
- Um
- Okay. (CHUCKLES)
It's so nice
to meet you in person. Um,
you look exactly like you do on chat.
You look better.
Um, do-do you want to sit?
I got us a table.
Yeah, we could.
Or, um
we could get room service.
(LOCK BEEPS)
(EXHALES SHARPLY)
You went all out.
What if you weren't attracted to me?
I wasn't worried.
Hobie McSorley from Pittsburgh.
Wendy Goss from Utica.
Are you sure you want to do this?
I mean, body mods are one thing.
We're talking about
getting into your genome.
I'm sure.
I want my first time to be with you.
Okay, this might be weird,
and it's definitely too soon,
- but
- Mm-hmm.
I think I want to say "I love you."
Well, it's not any weirder
than what we're about to do.
I love you too, Hobie.
Put it in me.
♪
(GASPS) It's working.
(LAUGHS)
Yours should appear any second.
Okay.
Hmm.
Maybe we should kiss.
- Yeah.
- Yeah.
Yeah.
(GASPS)
I'm sorry, Hobie.
I don't feel so great.
- What?
- Um
- You okay?
- No.
- Wendy?
- Um
♪
(SHINWELL CLEARS THROAT)
Sorry to interrupt.
It's the end of the day, Shinwell.
I think, at the end of the day
- I am aware of this.
- Ten minutes.
Ten minutes to review our cases
and think about next steps.
It's not an enormous ask.
No, it's it's an entirely
reasonable ask.
But I do wonder if, perhaps,
on this particular evening,
your ten minutes
can perhaps wait ten minutes?
It's the fellows.
They're struggling a bit
with the transplant.
WATSON: Okay, first, somebody's
gonna have to pick up the snot
and put it in the fridge.
Snot transplant.
- I don't like it. Sounds fake.
- It's real.
We're doing it tomorrow.
Remind me how we picked the donor.
By the quality of her snot, obviously.
Which is measured how?
Okay, enough.
Laine Sudow has had sinus
infections her entire life.
Tomorrow, we swap out her
bad snot for the good snot.
Problem solved.
But first, someone
has to preserve the specimen.
Y'all are such wimps.
(GROANS)
Thank you, Dr. Lubbock.
Where are you going?
To think.
John, you're still here. Good.
My body's still here.
My brain is looking
for someplace way far away.
I was going to ask you for a favor,
but if you're in your
special selfish genius place,
- it can wait.
- I don't have a special
selfish genius place.
What is it?
I won an award.
The Deltas are honoring me
for my work in the clinics.
I say a few words, I get a plaque,
my picture goes on the wall.
Wow, the Deltas.
That's huge. Congratulations.
Someone has to introduce me.
They talk about my work,
my volunteer commitments,
my good qualities.
Someone
Do I need to fill in the blanks?
Oh, so you want me
to give a speech about you.
About my professional
and philanthropic achievements.
You can leave the other stuff out.
I'm gonna ask Dr. Kim.
Okay, no, look, I will do it.
Of course I'll do it.
Give me the time, place
and the dress code,
and I'll be there.
Thank you.
Oh, John, I have to submit
the introduction ahead of time.
Two minutes or so.
Get it to me two days from now?
You got it.
♪
(MAN MOANING)
Sherlock?
Watson.
I was hoping to surprise you.
You've been sleeping
in the abandoned wing?
Just the past couple nights.
We've had worse, my friend.
Yeah, but why?
Ah.
It's under there, Watson.
(PHONE VIBRATES)
Awaiting the grand unveiling.
What's under there?
In 1929, the markets crashed.
The prairies turned to dust
and your country starved.
I know about the Great Depression.
And did you know that your government,
in an effort to keep people working,
commissioned a series of public murals
by the great artists of the day?
Some are as good as new.
Others have been lost.
That wall, John.
A mural by the late Charles Alston
under the paint there.
Looks like a wall, Holmes.
Well, you have to look deeper, Watson.
It's a miracle.
A masterpiece,
- waiting to be uncovered.
- (PHONE VIBRATES)
Holmes.
You have to look deeper, Watson.
It's a miracle.
A masterpiece,
waiting to be uncovered.
You just said that.
Did I? I don't think so.
No, yeah, you did.
Look, whatever this is,
let's go back to my place
and talk about it, okay?
(PHONE VIBRATES)
Hobie, I'm a little busy right now.
John, I need your help, John.
I need your help now!
What's going on?
It's Wendy. She's my, uh
I don't know, I don't know. We were
we were doing a CRISPR mod together,
and I was careful.
I promise I was so careful.
Calm down. Tell me what happened.
I love her.
I mean, I think I love her.
I told her I love her.
I'm in love with Wendy, Watson.
And I'm worried maybe I killed her.
♪
- (INDISTINCT RADIO CHATTER)
- ♪
♪
NURSE: Incoming. Room 3 is empty.
Wendy. Wendy, I'm Dr. Marcus.
Can you hear me?
Wendy Goss. Are you with us, Wendy?
Oh. You warned me.
You warned me over and over again.
Send a stat CBC and a chem 7.
You told me that
if I kept playing with DNA,
something bad
was gonna happen, but I thought
you meant me, you know?
I didn't care about myself.
I mean, not then, anyhow.
Okay, Hobie, you can
beat yourself up later.
I need to know what you two were doing
in that hotel room.
It was the first time
that we met in person,
and we wanted to make it special,
so I-I worked up a love mod.
What's a love mod?
It's a riff on the biohack
I used to make my chest glow,
except using bioluminescence
from red mushroom coral.
Me and Wendy
we were supposed to get
matching glowing hearts,
but only when we were together
and, you know, feeling
love.
You just met tonight.
How could you be in love?
Forget that.
We'll talk about that later.
So, if I'm hearing you right,
this glow
it's triggered by oxytocin.
The love hormone.
Okay, what about the heart shape?
They're tattoos, just using
my gene cassette instead of ink.
I-I mailed Wendy the serum so that
we could get tattooed
in time for her visit.
The injection at the hotel
it was just a booster.
It-it was Wendy's
first time messing with CRISPR.
She trusted me, Watson.
I know. Yeah, I know she did. Listen,
Wendy is my patient now.
We're gonna do everything we can
to bail you out of this.
I need a sample of the serum,
the booster,
your whole full schematic.
Wait, bail me out? What do you mean?
- Am I-am I in trouble?
- Your girlfriend is sick, Hobie.
You injected her with something
you cooked up in your garage,
and she's sick.
Now, are you in trouble? I don't know.
If we can't make her better
I don't know.
Wendy Goss. She's in the ICU
now with hemolytic anemia.
Her red blood cells
are popping like balloons.
So far, her kidneys are unaffected.
Let's focus on finding the cause.
It's the tattoo.
Innit?
In my observations,
I have observed
that a couple's tattoo
is the surest path to suffering.
I didn't mean the karma cause.
I was looking for the medical cause.
STEPHENS: Could be infection.
Her body mods put her at higher risk.
Or an immune-driven food allergy.
Okay, good. Good.
Let's test her antibody level
and start antibiotics.
Sorry, this woman mainlined
a garage juice CRISPR cocktail,
and we're worried about allergies?
We need to consider
everything, Dr. Derian,
but that is a fair point.
Wendy is a biohacker.
She's been experimenting with
mechanical additions and implants.
Hobie's love mod is the first time
she messed with her own genome.
So this could be genetic instability.
The labs are gonna tell us more,
but for now,
let's explore if Wendy's issues
come from her body mods
or Hobie's shot.
Sasha and Stephens,
hit the lab.
Check the serum and Wendy's DNA,
especially the sequence
that was targeted by that mod.
Ingrid and Adam, go to Wendy's hotel,
dig through all of her stuff.
See what else we can learn
about these mods.
Dr. Watson,
did you, by chance,
invite the Pittsburgh Police
this evening?
Detective Lestrade.
To what do I owe the pleasure?
Evening, good looking.
How do you keep your suit
so perky after sundown?
Maybe I sweat starch.
Maybe I don't sweat at all.
- How can I be of service?
- Not here to see you.
I need a word with Dr. Lubbock.
Me? Is everything okay?
Is there a private place
we could talk?
SASHA: He's dead?
Uncle Jun is dead?
A neighbor called in a wellness check.
We found him lying in bed.
There were a couple of
beer cans scattered around.
I recognized a photograph
of you on the nightstand.
You called him Uncle Jun?
What was the nature
of your relationship?
It's just how he introduced himself.
He said he was my uncle.
He said that,
uh, he knew my birth mom.
But the whole approach was a lie.
He was just looking for someone
to talk to.
What happened to him?
We don't know yet.
There were certain signs.
You think he did this to himself?
We have to wait for
the toxicology report
to get back, but,
uh, there's a gray area between
doing it to yourself
and letting it happen.
We call that a death of despair.
This kind of feels like that.
You hadn't spoken to Jun recently?
Not for a while. Uh,
not since I figured out
he was lying to me.
He died alone?
I'm afraid he did.
It's a sad situation, but this
is not your fault, Dr. Lubbock.
If you're interested, I could
let you know what I learn.
Uh
This is a hospital room, not a crypt.
Well, I'm trying to make up
for the fact that
our first date ended up in the ICU.
Hobie, you told the triage nurse
that Wendy had an RFID chip
made of bioglass
in the back of each hand.
We haven't seen
any sign of infection there.
Are there any other body mods
that we should know about?
The finger magnets. And she has
a transmitter in her ribcage.
Wendy told me
that it was supposed
to send her body temperature
to her thermostat.
There were complications.
Okay, so we'll test
for metal toxicity.
We'll also measure
her cytokine levels.
Okay.
She's jaundiced.
Looks like her anemia's getting worse.
Half my team
is looking over her labs,
the other half
is digging through that hotel room.
We'll know something soon.
- Okay.
- But Hobie,
why did you do this?
Love.
I wish you'd stop saying that.
You can't love someone
you met five hours ago.
You disagree?
I disagree because you're wrong.
Judge what
we did, what I did, but
don't tell me who I can love.
You're not that good of a doctor.
(DOOR CLOSES)
It looks like a Hallmark card
threw up in here.
No visible signs
of mold or pesticides.
I'll check for moisture.
You want to check the fridge?
You okay?
Ingrid, you're staring.
Nothing's gonna, um
happen here. You realize that, right?
Happen? Ew. What could possibly
make you think
that something might happen?
We're in a hotel room
and you're staring at me.
I'm not staring at you,
I'm judging you.
I'm deciding if
I want to tell you something.
Oh. Okay.
What is it?
I'm in the middle of a situation
that might not be so great.
I can't talk to anybody about it
because they'd have opinions.
You're kind of a blank slate
human void, if you will
so you might be safe.
That is so sweet.
Remember Beck? Beck Wythe,
like "lithe" but with a "W"?
You mean the guy who stabbed
a man in the neck
with a pair of scissors
right by my desk?
I do remember him. Yes.
I go over
to his place sometimes.
We take off our clothes.
That kind of thing.
And are you asking me
if you should stop?
Because you should definitely stop.
(SCOFFS) I know what Beck is.
In fact, I hold him in contempt.
But there is one specific thing
that he's very good at.
In my head, there are compartments.
And in one drawer
is who Beck is,
in the other drawer is what Beck does.
They're the same drawer.
Sasha guessed it.
I told her I'd stop.
- I do feel bad about that.
- (SHORT CHUCKLE)
You've come a long way.
Not nearly far enough, but still.
I'll break this down for you.
There's you.
You're a mess.
Dangerous at times,
but still, you know, Ingrid.
And over here,
there's Beck.
And he is something
different altogether.
I don't care if you guys
go to the same therapy group
or if you have the same
diagnosis or whatever.
I was locked in a room
with a man strapped to a bomb
and with Beck.
Beck scared me more.
End this.
Don't overestimate yourself.
Huh.
She has chikke'en in her fridge.
Didn't Hobie say that Wendy was vegan?
No, not chicken.
Chikke'en with two Ks.
Does it make a difference?
I don't know.
I'm gonna text Watson the ingredients.
(HOLMES MUTTERING)
Sherlock.
(HOLMES STAMMERS)
Ah.
Were you watching me?
What's going on with you, Holmes?
I don't just mean
the camping out at the hospital.
I mean the faking your own death,
disappearing acts, the paranoia.
Spray-painting
the walls at my hospital.
What's going on?
I've been thinking about dying, John.
I'll be gone
soon enough.
We'll all be gone soon enough.
But right now,
today, here, on your couch,
my mind still works.
Now, look, I could solve crimes
until I keel over, and I'm not saying
that's time wasted.
But what is true
is that the very moment
the exact, literal
moment of my death
someone somewhere
will murder somebody else,
and I haven't really
changed anything, have I?
I haven't left anything behind.
You've helped people, Holmes.
You've given families justice,
peace of mind.
Is that what I owe the world forever?
A finger in the dam
until the day I die?
I want my choices to outlive me.
I know that sounds vain.
But if I can be just a bit kinder.
If things can be a bit more fair.
If I can show people something
something beautiful
that's been covered
under paint for decades,
that's something, isn't it?
"Sherlock Holmes was here."
The older I get,
the louder I want
to shout that into the void.
Stupid.
You don't have
a cuffed shirt on, Holmes.
Your left hand you're plucking away
at your right wrist,
same as you did yesterday.
You're concerned about my behavior.
I wouldn't call it behavior.
It's more like symptoms.
No symptoms, John.
- (PHONE VIBRATING)
- My priorities are shifting.
Isn't that what friends do?
Stand beside each other
through life's changes?
Hobie.
She's peeing blood, Watson.
Calm down, Hobie.
Wendy slept through the night.
She seemed maybe,
I don't know, like,
a-a little bit better?
And then she
started crying in the bathroom.
She's peeing blood.
Okay, don't panic.
Okay, this could be anything.
Could be benign.
And there's no doctor here.
We keep asking for a doctor.
Okay, I'll be right there.
Just stay calm
and help Wendy stay calm.
Okay.
HOLMES:
Not to call you out, my friend,
but whatever that is,
it doesn't seem like
you believe it's benign.
I think my patient's kidneys
are failing.
My kidneys are failing?
You have hemolytic anemia.
We're hydrating you
as aggressively as we can.
That should help protect
your kidney function.
You will be here
for a little while, Wendy.
Is there anyone you'd like us to call
or anyone you think should travel?
Um, I should call Parker.
She's the other paralegal
in my department. She
she's watching my cats.
I'll do it.
It'll be fine, I promise.
- Okay. Thank you.
- Yeah.
Anyone else?
Do you have someone, Dr. Watson?
Yeah, I do.
You should go to her right now.
Him, her, whatever.
Wrap your arms around her.
Time gets short really fast.
It's Laila. She's traveling.
But there is an underlying
cause to this, Wendy.
You and Hobie took
the same CRISPR treatment.
There's a reason why
it's affecting you and not him.
If we can figure that out,
then we can get you better.
I hope that happens.
Last night things seemed really good
for the first time in a long time.
But if something happens, if I
go on dialysis, if I can't talk?
I consented.
I knew everything about CRISPR.
I understood the risks.
I did it because I wanted to do it.
(SIGHS)
You have to tell people that, okay?
You have to tell them
it wasn't Hobie's fault.
Wendy Goss did not have a good night.
I don't know how many more
bad nights she has in her.
Who's got something for me?
Adam and I came back to Point House
to talk to employees
who weren't here last night.
Wendy asked a desk clerk
to send up loperamide.
She was worried she got food poisoning
from a french fry sandwich.
GI symptoms, huh?
We were thinking
hemolytic uremic syndrome
caused by a shigella infection.
She's already on antibiotics.
If it were bacterial, her
symptoms should be improving.
Remind him about
the chikke'en with two Ks.
Adam asked me to remind you
about the chikke'en with two Ks.
I'm aware of the fake chicken.
If it becomes relevant,
I'll let him know.
We're double-checking Wendy's samples.
The sequencer shows
clean serum, clear targets.
Sasha's working on a karyotype.
And she's okay?
She seems fine.
She's been quiet.
You sure about that?
A man died yesterday
with Sasha's picture
on his nightstand.
She keeps saying she's fine.
She wants to work.
WATSON: All right, Stephens,
let us know what comes back.
Ingrid, tell Adam
to stick around the hotel.
We should interview
every staffer who talked to Wendy.
INGRID:
Sure. Am I not doing that, too?
You're coming back to UHOP.
I need to see you in my office.
Wait, am I in trouble?
Hey.
I am still making that list
of all your good qualities.
Might take a minute.
Actually, I heard back from Dr. Kim.
She was on vacation with her family.
Turns out she can do it, so
Wait, hold up. Hold up.
So I was your backup choice?
You're busy, John. You're always busy.
Dr. Kim is my mentor.
Wow, so I was your fallback, huh?
(SCOFFS)
Consider yourself off the hook.
Look, I appreciate it.
I really do.
All right, wait. Hold up.
I want to do it.
Okay? Look,
I'm not gonna force my way in,
but, yeah, I want to do it.
So I tell you what.
If you asked Dr. Kim
because you think that
she'll give a better speech,
I'll bow out.
But if you think I'm too busy
or I might blow it off,
I'm not and I won't.
If you want the John Watson Special,
I will be there and I will deliver
the John Watson Special.
You good?
Yep, I should have Wendy's
karyotype ready in a second.
No, I mean, um
are you good?
That was awful.
That man Uncle Jun or
(SCOFFS)
whatever we're supposed
to call him now.
That was terrible news.
You were kind to him.
Even after you found out he was
scamming you, you were still kind.
I don't know if he was scamming me.
He didn't ask for money. He
just wanted someone in his life.
I feel sorry for the man,
but how you treated him?
It was better than
he had any right to expect.
Who do you think he was?
How did he get
that baby picture of you?
Before he came here, he worked
for the Chinese government.
There are layers at these
international adoption agencies.
Jun worked for one of them.
- You never told me that.
- I didn't know.
If it's even true, I didn't
know until this morning.
Stephens, I got an email.
A-Apparently, before he died,
however he died,
Jun passed
my contact information along.
Passed it to who?
Read it for yourself.
"Dear Sasha, my name is Shu-Yi."
Oh, my God.
Is this real?
I don't know yet, but if it is,
I just got a message
from my birth mom.
What do you want me to say here?
I want your opinion.
I have this friend who has
been behaving differently.
It's little thing, big things.
It all adds up
to a pattern I'd call erratic.
I'm concerned.
Well, you're right to be worried.
These little blank moments
in the middle of a conversation,
they could be
complex partial seizures.
There's no history
- of epilepsy?
- No.
The repetitive movements,
they also don't sound good.
We call it "meaningless reaching."
But you are John Watson.
You know all this.
But I'm not sure
that I can be objective here.
Tell me tell me
what you see, Dr. Derian.
This friend of yours, whoever he is,
he's displaying symptoms
that could represent a brain tumor.
He could be very sick.
Your friend needs to come see me.
Today.
(KNOCK AT DOOR)
STEPHENS: Watson,
we just finished
Wendy Goss's karyotype.
You need to see this.
The karyotype on the left
is from a healthy human female.
The chromosomes
on the right are Wendy's.
Look at this.
INGRID: What is this?
Half of Wendy's
X chromosomes are shattered.
It's definitely not chemical exposure.
We would have seen it
on the comet assay.
Could it be a virus?
Shiga toxin, maybe?
No, it's too clean.
Viral damage is messy.
SASHA: It can't be the love mod.
She just got that yesterday.
It's not Hobie's mod,
but it definitely looks
like CRISPR damage to me.
It's the only thing
that could have shredded
her chromosomes like this.
The love mod was the first time
Wendy edited her genes.
That's what she told us.
She was lying.
Wendy's used CRISPR before.
She did it so often
or was so sloppy with it,
she wrecked her own chromosomes.
There's so much damage.
We may not be able to help her.
I'm sorry. I should have told you
I hacked my genes before.
Hobie was here. I'm sorry.
I don't follow.
Hobie plays with his DNA
like a Rubik's Cube.
Why would he care?
I kind of left it out at first.
Then the more we talked,
the more excited he got
about me doing my first mod with him.
It was a new thing.
I wanted it to become a real thing.
I let Hobie believe
what he wanted to believe.
About a year ago,
I placed three
extra olfactory subvariants
in my OR3A subfamily.
You enhanced your sense of smell?
I have cats. They have
200 million scent receptors.
I wanted to
I don't know, see what
the world is like for them.
It's stupid.
Are you gonna tell Hobie I lied?
No, no, that's your job,
if you want to do it.
My job is to figure out
why CRISPR damage from
a year ago has you in the ICU.
I sent him home to get some sleep.
I'll just send him an email.
If he doesn't want to come
back here, he doesn't have to.
(KNOCK ON DOOR)
Watson, I just
got back from the hotel.
I heard about the karyotype.
The chikke'en with two Ks
Yes, yes, I'm aware of the chikke'en,
and I'm aware of the two Ks.
The protein in there,
they make it with fava beans.
Does that matter?
The humble fava bean.
It can trigger extreme
hemolytic anemia
like Wendy's but only when
a patient suffers from
A G6PD deficiency.
When Wendy took those passes
with CRISPR,
she triggered a mutation in this gene.
- You knew this?
- Mm-hmm.
- You've come a long way.
- Thank you?
Not nearly far enough, but still.
Wendy hasn't had fava beans
since she was admitted here.
Shouldn't the transfusions
have made a difference by now?
The antibiotics.
We've been trying
to stave off infection.
99% of the time,
that's the right move.
But with this mutation,
it actually makes things worse.
We can help her.
We can do better than that.
Wendy's chromosomes
will be damaged forever,
but she can live.
We'll adjust her medications,
and hopefully,
with one last transfusion,
she'll be back on her feet.
She can lead a full life,
but only if she avoids
a few medications
- and
- Fava beans.
Fava beans.
Adam and Ingrid,
monitor Wendy's progress.
Sasha and Stephens, dig into
the backlog of our remote consults.
We should be wrapped up here soon.
You okay?
Can I show you something?
STEPHENS: Wow.
You're really gonna send this?
I think I am.
It's not crazy that she reached out.
Jun wasn't my uncle, but he did have
a connection to my family.
I believe that he felt guilty
for what he did
and passed along my information
before he died.
Look, if it's something else,
if she asks for money
or if it's a scam,
I'll never respond again.
I guess I just don't see a downside.
I don't know.
Disappointment, I guess.
What do I have to be disappointed for?
I'm living every dream I ever had.
I have a family already.
They can be
annoying as hell sometimes,
but they ain't going anywhere.
(STEPHENS CHUCKLES)
I have you.
I'm gonna be fine.
Whatever comes back,
I'm going to be great.
WATSON: I knew I'd find you here.
Well, I'm always happiest
when I'm working.
You know that.
You don't believe me, do you?
You don't believe it's under there.
- I don't think it matters.
- (LAUGHS SOFTLY)
You're a genius, Sherlock.
I would never question that.
But I'm
not thinking about
what's under that paint.
Remember Alexander Petrov?
The Cobalt Fissure?
A three-day pursuit
chasing our quarry
across the Russian steppe?
How could I forget that?
Yeah, it was a three-day pursuit
that ended with us
surrounded by soldiers
in biohazard gear.
I think about it all the time.
It was three days.
Three days exposed to,
to God knows what.
I think you're sick, Sherlock.
I think there's something
growing inside you.
Everything that you've been doing
the faking your own death,
the paranoia,
the secrecy you're not yourself.
It hasn't been easy, John.
I'm Sherlock Holmes.
I know exactly how to solve a problem.
I'm not afraid of a mystery.
I'm not afraid of anything.
It hasn't been easy.
So come on into the hospital.
I will keep it as quiet as I can,
but you need to see a neurologist.
Forgive me if I'm nervous.
It's been a while
since I've felt this exposed.
WATSON: It's right here. This room.
So, wait here,
and I'll go get Dr. Derian.
ADAM: Your numbers
are looking good, Wendy.
Transfusions are working.
You don't seem happy.
I haven't heard back from Hobie
so I guess we're done.
Okay, so you maybe lost
a potential boyfriend.
Bummer. But you're gonna live.
(DOOR OPENS)
Scent receptors?
- Cats?
- I'm sorry, Hobie.
Did you think I would care
about any of that?
Did you think
I would care for one second?
INGRID: We'll give you two a minute.
Oh, my God, Hobie, it's working.
(LAUGHS)
I thought about what you said.
I'm gonna end it with Beck.
I think that's a good idea.
I appreciate you taking my advice.
I thought about what you said.
And when you get down to it,
penises abound.
(CHUCKLES)
Yeah, I guess they do.
And you have to sort through
a pile to find the one
that does what it's supposed to,
but penises abound.
(FOOTSTEPS APPROACHING)
Watson?
- Everything okay?
- HOBIE: I need your help.
- I need your help.
- (ALARMS SOUNDING)
I kissed her.
A-All I did was kiss her.
We need some help in here.
What is happening?
Let's get her on some oxygen.
What happened?
What-what-what did I do?
What did I do?
- What happened, Hobie?
- I already told you.
- I kissed her. That's it.
- The tattoo on Wendy's forearm.
It glowed. It didn't before,
but right before you kissed, it did.
HOBIE: Does that matter?
I thought that just meant
she didn't love me until now.
Watson.
Does that matter?
Wendy's inflammation inhibited
her flow of oxytocin.
When we stopped triggering her
with antibiotics,
her love hormone could flow freely.
ADAM: That explains the glowing,
but what's wrong with her?
I think we have uncovered
a new allergy.
We're gonna be fine.
Wendy's gonna stabilize,
we'll reverse her love mod
and she's-she's gonna be fine.
(EXHALES): Okay.
If Wendy's gonna be fine,
then why do you look so sad?
We fixed Wendy's response
to the fake chicken
with the fava beans.
Now that her oxytocin's
flowing freely,
she's having a reaction
to the tattoo's
bioluminescence proteins.
Like I said, we have to reverse
the love mod that you gave her.
Great.
I how is that not great?
Your chest, Hobie.
You. You're filled
with the same proteins.
Wendy's not just allergic
to the tattoos.
She's allergic to you.
You can't be around her.
You will kill her.
So, reverse it. Take away my glow.
- Who cares?
- You know I can't do that.
You've been playing God
with your own genome for years.
I mean, to walk all that back
The number of genes
that we'd have to open up
There's no map.
You'd experience
genomic instability
off-target mutations.
You'd probably die.
I'm not gonna help you do that.
INGRID: Watson.
We've got her stable.
WATSON: I'm sorry, Hobie.
Wendy's gonna live. You're gonna live.
You just can't be together.
(EXHALES)
SHINWELL: You wanted to see me, guv?
He's alive, Shinwell.
Holmes. He's alive.
Wow.
"The Pittsburgh Mystery."
Holmes mentioned this.
I was meant to keep it secret.
I've had me suspicions, guv.
Ever since you first used that phrase,
- I've had me suspicions.
- No.
Holmes is sick.
I think he's very, very sick.
We have to find him, Shinwell.
("LONELY IS THE NIGHT"
BY BILLY SQUIER PLAYING)
- Hobie.
- Hey.
What are you doing?
You can't be here, Hobie.
Maybe not yesterday, but today
I'm right where I need to be.
Wendy, can I show you something?
Just give me 30 seconds,
and if you want me to go,
I'll go.
STEPHENS: You did it to yourself.
- You've reversed your mods.
- WATSON: What's the matter
with you, Hobie? You could have died.
- You still could.
- WENDY: Why?
Why would you do that?
You're the Man with the Glowing Chest.
No. That's not true.
The only reason I ever glowed
was so that you could find me.
♪
You are here now.
The technology's obsolete.
Hobie.
MARY: I know things
got crazy here today.
I'm letting you off the hook.
I wrote it.
I told you I was gonna do it,
so I did it.
Thank you.
(INDISTINCT CHATTER)
INGRID: This isn't a good idea.
- Hi.
- Don't interrupt.
This isn't a good idea.
You're not a good idea.
Okay.
"Okay"?
We're two bad people, Ingrid.
Two bad people doing
a good thing for each other.
But if it's not working
for you anymore
I get it. I'm good.
If you change your mind,
that's okay, too.
You know where to find me.
(LAUGHS SOFTLY)
I expected
I don't know,
a-a fight, a scene. Something.
(LAUGHS SOFTLY)
It's okay.
Well, therapy is about to start.
Yeah, I'll be in in a few.
I just got to finish this.
♪
I can't believe it,
and you're incredibly lucky,
but you're doing just fine.
That was really stupid, by the way.
I know that.
Of course I know that.
(SIGHS)
Your girlfriend. Laila, right?
- Is she back in town?
- Yeah, I saw her last night.
HOBIE: And yet something tells me
you still haven't done the deed.
We're grown-ups, Hobie.
Of course we've done the deed.
No, I'm not talking about sex.
Have you told your girlfriend
that you love her yet?
Again, we're grown-ups.
We're doing things at a grown-up pace.
(SIGHS) You're a
smart man, John Watson,
so I'm sorry for saying this, but
you can be a real idiot sometimes.
- Life is hard.
- Hmm.
It's hard and it's confusing
and it's lonely.
And we all live in the middle
of that, and sometimes
we are lucky enough
to find someone to love.
To have someone
who might love us back.
And if you've got that,
it's not time to be smart.
It's not time to be a grown-up.
If you're not willing to lay
yourself on the line for love,
if you're not willing to be stupid,
then why do you even
deserve love in the first place?
Now, I'm glad I am doing better
but I think you should go now
and find the woman you love,
and I think you should
tell her all about it.
Lonely is the night ♪
When you find yourself alone ♪
Your demons come to light ♪
And your mind is not your own ♪
- Hey, is she in?
- Conference room, but she's in a meeting.
Sorry, this can't wait anymore.
- And it's a high time to ♪
- Mary.
MARY: John. What are you doing?
sync & corrections awaqeded