ReGenesis s01e06 Episode Script
The Trials
Mad cow.
Where do you find prion samples? In 4 dead people.
These chickens could be carrying a fucking death sentence for millions of people.
What can we do for those who are potentially infected? There is no cure.
Where are you going? Don't you want me to come in with you? Go back to your lab, Dad.
- Lilith, moved in.
- Wow.
- What is she like, 14? - 15.
Tons of attitude! Hira's replacement.
- Are you still interested in Jill Langston? - Absolutely.
What do you want me to do about David? Maybe in Chicago when he's there next week.
Good morning.
It was said of the Spanish Flu, that you felt a little ill at breakfast, went to bed after lunch, and were dead by dinner.
What would you say if I told you I've got a lead on the perfect specimen? Bullshit.
So can I take a couple of days? I'm playing with this guy Archambault, 32.
His heart exploded, David.
Instead of injecting something into him that shouldn't be there, he gets his body to make it.
So Biriliski and Archambault died to avoid a patent infringement? You don't understand.
You can't do it anymore.
You will die.
Fuck you, David.
You're a big shot scientist.
I'm nobody.
How is he? Ah.
.
He's gonna be okay.
He's a tough guy.
And that's about it.
Good.
Ah one more thing.
Yes.
I'm sorry about last week.
I shouldn't have put you on the spot like that.
No.
I admire your integrity.
Even more than I appreciate your keeping Dr.
Sandstrom from going public on this prion thing.
Let's just hope we stop this thing soon enough.
Caroline, I need a personal favor.
A colleague of mine, James Bainbridge, his son Ryan was diagnosed with leukemia about six months ago.
They were admitted into a trial for some new treatment.
I'm not up to speed on it, but they tell me it was incredibly promising.
Was? There is some question about it's safety.
And you'd like NorBAC to get involved? Senator Bainbridge and a lot of sick kids would.
And.
.
Jim would see it as a favor.
And he does sit on a Senate's Science and Tech Committee.
- Garcinia cola.
- That's a plant.
Comes from the same place where ebola lived.
Never heard of it.
A big deal at the International Botanical Congress.
Traditional African medicine.
Poison antidote.
And it works on Zaire Ebola? It works on any strain from what I've read.
It's amazing.
It's a dimeric flamanoid, and if it stops Ebola replication in its tracks You think it's worth throwing at the Miranda Virus? Why not? You got the DNA sequences back from the dental floss yet? Bob should have it this afternoon.
Where is Bob? - He's waiting for us at the hoop.
- Aw, you didn't tell him.
What am I suppose to say, David? Oh Bob, you're too good, you can't play basketball with us? Yes.
Where are you going? Wait.
What meeting? - Left a message on your machine.
- I didn't check it.
Of course.
We've been asked to mediate in the dispute between two researchers in a clinical trial.
- David! - I don't do bureaucratic bullshit.
This bureaucratic bullshit has a US senator attached, who will help give your bank financed and give you every new toy you want.
Who's running the trial? - Julius Booker at the University.
.
- Is this about the new gene therapy treatment for Acute Myeloid Leukemia (AML)? You know about it? I heard they got shutdown, what happened? - One of his test patients died.
- Well, that hurts, but people with leukemia do die.
Why'd they pull the plug? One of his lead researchers, Lauren Folley, claims that.
- Lauren Folley? - You know her? Let me get my coat.
Hello, Robert.
Miss Richmond.
Why don't you get in? All right.
Robert, why don't you come around to the front? All right.
Robert, you're not doing anything wrong.
I feel like I am.
I always have.
Robert, we've had this arrangement for over a year now.
I know I know.
It's just.
.
I don't know what they'll say if they found out.
Well, let's make sure they don't find out.
And the paperwork? Thank you, Robert.
Thank you, Miss Richmond.
Come in.
Dr.
Folick, Caroline Morrison, NorBAC.
Lauren, please.
- Pleased to meet you.
- Nice to meet you.
David.
Long time.
Lauren.
Ahh We were biology undergrads together.
- Back in the dark ages.
- Very dark.
Very dark.
- So I guess we've been invited to the party.
- Yeah.
I'm glad.
I feel like I'm out there all alone.
- Come in.
Sit.
- Thank you.
So, Lauren you think this is a questionable treatment? Not questionable.
Maxwell Peterson was 11 years old.
He was a wonderful, bright boy.
He was diagnosed with leukemia a year ago.
Do you got any proof that the therapy caused the stroke? Well, he died just 4 hours after receiving the treatment.
No, I meant scientific proof.
You know hard numbers, data, that kind of thing.
No.
Not yet.
So you just jumped to the conclusion that the kid died from the injection.
Gene therapy is about injecting a virus.
A good virus.
It goes right into the cancer cells and kills them.
- A "Magic Bullet.
" - I see.
I think that the Peterson boy's system over responded.
Maybe the dosage was wrong - Maybe it was the timing - But you don't know.
.
Neither does Booker.
You brought this up with the internal review board? Yeah, I asked them if they could believe if this was just a coincidence.
Well, did you ask them if it was just a coincidence that the other two patients got better? Look, David.
The point is Booker just wants to plow ahead.
And write this stroke off as a normal occurrence in an AML patient.
Well, he's not wrong.
Is this something that the chief scientist on the project should just ignore? Why would he do that? The university's job is to keep money flowing into research.
And Booker is a money magnet.
Someone's got to do it.
Come on, David.
Cancer treatment is a 20 billion dollar a year business.
If Appliex is the first to market this gene therapy they are going to make a fortune.
Appliex Pharmaceuticals? Yeah.
Wow.
You're butting heads with a hell of a pharmaceutical company.
Yeah, well.
They've had their failures.
Give me a drug medic that hasn't.
Look.
I just think that we need to step back and ask ourselves some hard questions.
I see.
So instead of working with Booker, you just decided to go over his head and blow the whistle on him.
You haven't changed a bit.
I'd say you haven't either.
- My data.
Keep an open mind.
- I will.
- Very nice to meet.
- Nice to meet you.
I wouldn't be surprised if this is her "Best of Celine" collection.
What's the matter with you? I hate Celine Dion.
What's wrong? Folley.
She's so textbook.
She's got no imagination.
She just gets on the tracks one direction.
One conclusion, one answer.
Had been that way since the day I met her.
What? You two had a thing, didn't you? - Where did that come from? - Did you? You know how it is in university, I mean, everybody's sleeping with everybody else.
.
You were sleeping with everybody else? No.
Not everybody.
Oh come one you trying to tell me you didn't sleep around? I don't see that's any of your business.
- Well you're judging me.
- Yeah, just like you're judging Lauren Folley - As a scientist.
A bad scientist.
- Can you be objective? Yes.
- Hey.
- Have you been waiting long or what? No really, no.
So what do you want to do? I don't know.
That.
Looks like fun.
Mick, skaters are losers.
Didn't know that.
So uhh.
.
what's the coolest thing you've ever done? Wow.
That's a huge question.
Like anything.
Like uh.
.
Seen, done or whatever.
Doesn't matter.
I saw a corn-snake eat a mouse.
Like just whole.
Come on you can do better than that.
- Okay, I shaved off all my hair.
- Yeah.
Why? Because I was bored.
I don't know.
Oh I know, a whale.
A whale winked at me.
What do you mean? We went whale watching and we were on the boat and this huge whale, like totally humongous, comes up and it was this far away, I swear, it just came out of the water looked at me and I swear to you, it winked.
It winked at me.
Man.
I want that.
What? I want a whale to wink at me.
- A whale? - Yeah.
- Um.
.
Where are you gonna find a whale? - The ocean.
Whatever, we'll find it.
promising treatment I've ever worked on.
- Is it the safest? - The whole point of the trial is to find out if it's safe, but I can't believe Folley's allegations.
You know we're looking at fast-track designation with the FDA on this? Do you think Folley is way off base here? Well, she's jumping the gun making decisions based on emotions, not science.
Wouldn't be the first time.
A child did die in the trial.
The boy was sick.
He died of a disease that we were trying to save him from.
You see cancer cells, they multiply at an extremely high rate.
We deliver a simple cold virus that makes an RNAi.
RNAi, it's a new method for eliminating proteins like AML-6.
And the RNAi kills the mutant protein in the cell, and cell growth is arrested.
We're tricking them into committing mass suicide.
- Apoptosis.
Wow.
- Exactly.
The RNAl is encoded with an EBV derived plasma under a poll 3 expression.
Now the plasma is targeted to the tumor cells and a viral vector harboring a humanized anti-CD33 binding protein.
Because CD33 is highly expressed in AML cells.
That's it.
See it's a triple barrel approach.
We attack the specific molecular defect in an AML cell, we induce apoptosis and we can even insure higher specificity by using the CD33 binding protein.
It's amazing.
Because of one death, this treatment is going nowhere? See why I'm so Pissed off? Yeah.
I like a man who's not afriad of being a rude, pompous, arrogant, asshole.
That's why we get along so well.
Caroline, what Booker is working on in there is leading edge science.
Folley was one of his senior scientist.
She's over interpreting based on one observation.
Okay, do me a favor.
Explain to me what he was talking about in there? - And don't gloat.
- Okay.
If I had two samples of the same virus, and I put them ideal condition, right? Turn the lights down low, put on a little Barry White - I got it.
- I'd never get a third virus, because viruses don't reproduce that way.
- Thy're asexual.
- Ah you've been doing a little reading eh? Go on.
So in order for a virus to reproduce they've evolved this neat little tricks of breaking into a host cell, killing the boss, taking over, "Okay, you guys are working for me now.
" Pretty soon you got all these nasty little viruses out there and the neighborhood's shot to hell.
Okay.
Okay, so in gene therapy, you take a virus and you alter it, right.
You remove all the nasty bits and replace them with something good.
And now you've got the best delivery system mother nature has to offer.
Because if you inject a few trillion of these nicely altered little viruses into a patient, the viruses will just do what comes naturally, and they will break into - the patient's cell.
.
- And kind of infect them with health? - Pretty amazing, eh? - Yeah.
It is.
Yeah? Hello.
I can barely hear you.
Oh Joe.
Yeah, yeah.
Are you sure? Fucking sure is good enough for me.
I'm on my way.
I'll call you with my details.
On your way where? You know, I gotta.
Here you.
You go ahead.
I'll catch a cab.
- Everything okay? - Oh yeah, yeah, fine.
Fine ahh.
Make sure Carlos gets those and have him start on the evaluation.
- You're not gonna handle this? - What's wrong with Carlos? - Nothing, but.
.
- I love it when you agree.
Where are you going? - Nunavut.
- Nunavut? That's like way up there.
Yeah, permafrost catchy.
And you're doing this why? Because I've been chasing this Spanish Flu ever since I was your age.
Why? Because it killed more people than any other virus known to human kind.
Right, and that's something that excites you.
Yeah! Something that you can't see with the naked eye and wipes out an entire civilization.
It's the bomb man.
Eww So, when are you gonna be back? Ahh I don't know.
Depends on the flight, which depends on the weather.
And this is very important for your trip? I don't know why it got in there.
- You're so weird.
- Okay so, listen.
This is for food, and you know whatever else you might need it for.
You gonna be okay on your own? - I've been my own for half my life.
- Nice.
It's not a slam, it was a reassuring observation.
Ah well, thank you then.
Okay.
I will see you.
I will call you.
If Mick you know, he had a dream too, he should like, totally go for it.
- Absolutely.
- And I should help him.
- Of course.
- Yeah, okay.
- Bye.
- Bye.
Mick, hey hey.
Hey, you ready? Got a magic card.
You drive like a madman.
I didn't see any traffic signs.
Is this it? That's why it took over a year to find it.
Church record said it would be out here somewhere.
I found the dog tags right over here.
This here is your Mr.
George Edward Plane.
In the permafrost since 1918.
What are you doing? It smells good.
Oh.
Bob, I read your report.
No doubt in your mind? Bob! Oh, Good night.
The dental floss DNA, 100% certain it's him? It only takes 10 DNA matches to convict a man to criminal case.
I've given you 20.
Zansinger is Martin Jamieson, the biological father of Daisy Markowitz's baby.
I guess we should be grateful for a terrorist who flosses.
I'm greatful for anyone who flosses.
Um, have we started reviewing the AML trials? David on top of it? We don't know where he is, do we? - He probably does.
- Yeah.
Good night, Bob.
Need some help? No, I'm okay.
What the hell is that? It's his coffin.
Should I be wearing one of those? Oh, no.
Just ah.
.
Stand back a little bit there Joe.
So you done this before? In The old days med students had to find their own corpses, so we're just part of a grand old tradition.
Grave robbing? Oh, you're fucking beautiful.
You are one sick seal.
Polar bears can smell that guy from Come on.
Help me put everything back.
And I mean everything.
So So, now I do some ITPCR and some sequencing to see how degraded the RNA is.
So, how about my money? Oh.
Sorry, man.
And Joe, I tell you, if this works out.
I'm gonna get you ten times this.
I won't hold my breath.
You keep this between ourselves, right? Your dead guy will talk before I will.
Actually, I'm hoping he'll tell us plenty.
Your ride's here, Dav.
Okay.
It was a pleasure doing business with you.
You got any more frozen bodies, you know where to find me.
I got what I need.
So what did you tell your dad? The truth.
You told him the truth and you're still alive? - Yeah.
Well, I left a note.
- Oh, great.
It's not that I'm going to lie.
What I'm doing is not wrong.
Just checking Mick, those are a lot of pills.
Mick, Mick.
Maybe this wasn't a great idea.
I, I.
.
It is.
It is.
Amazing idea.
Okay? Hi honey.
I'm home.
Lilith? Hey dad.
Um.
.
Did you find that virus? Okay now.
Don't freak.
Mick and I went off to look at whales.
So.
.
Okay bye.
It's Lauren.
I wanted to talk to you about the other day.
My cell is 41.
.
Hi David.
Caroline asked me where you were today.
Of course I didn't say anything.
Mainly because I'm not really sure where you are.
If you want to call me and tell me where you are so I can tell Caroline.
, that would be really great.
And I hope you're having a fun time wherever you are.
Hi.
Hi.
- I called.
- Yeah.
I just ah I literally just walked in the door.
Look, ahh, David.
I know that you think of me as that knee jerk grad student and that you don't have a lot of respect.
Do you want to come in? No.
And I want you to know that I'm not the same person that I was back then.
So you're not gonna spend the night? I just.
I ah.
.
I truly believe that Dr.
Booker is making a mistake by not stopping and looking at the data on his gene trial.
Yeah you made that pretty clear the other day.
I want to work with you to make sure that these are safe.
Or.
.
- Sure you don't want to come in for a glass of wine or? - No.
Just look at the data.
And run every test that you can.
You might be saving a life.
- Thanks for listening to me.
- Sure.
- Albert Einstein, right? - Ah.
.
No actually "Mork from Ork".
Oh.
I get those two mixed up all the time.
- Mayko Tran, I'm over in Informatics.
- Jill Langston, virology.
- I know.
Nice to meet you.
- Nice to meet you.
So you had the tour? Pretty awesome, huh? Yeah, it's incredible.
Is that lunch? Sort of.
Rabbit food.
- Come on.
I'll show you where the fridge is.
- Okay.
- So you're hooked up with David in Chicago.
- He interviewed me there, yeah.
Did he behave himself? - I don't know what ask.
.
- It's okay.
That's why we love him.
Hello David.
How is ah.
.
Where were you? Whose shit is this? Oh.
The new virologist.
She's already made herself home.
What new virologist? Oh shit.
- What's wrong? - Nothing.
What's she doing here? - You hired her.
- I did? I'm confused.
Hello David.
This is Jill Langston.
I know.
- She say that MIT, Stanford, Princeton.
.
- Not now Bob.
What are you, ahh? I mean.
Can I ahh - In my office right away.
- Sure.
So no one told you I accepted the offer.
I was out of town.
- I hope it was a pleasant surprise.
- No.
I mean, I mean.
Yes it was.
It It was just.
.
I thought.
- Hi Caroline.
- Hi.
- So you got Jill, eh? - Yeah.
- You're settling in? - Yeah.
Yeah.
Everything's great.
Find an apartment? - I got a lead on a couple.
- Good.
Good.
Jill was one of my early consultants when NorBAC was going through committee.
Really? I didn't want to prejudice you until you two had a chance to meet, but I'm happy it all worked out.
- Yeah.
Here she is.
- Yeah.
So I was just gonna take Jill into my office.
Get her up to speed, that sort of thing.
- Well, you better get right to it.
- Okay.
Ah.
.
Isn't that gonna look a little suspicious? What? Closing the blinds.
What? - You're closing the blinds.
- Yeah.
I do it all the time.
When you have a woman in your office? Yeah.
So.
Is it gonna be okay for you? - Sure hope so.
- Me too.
Oh shit.
Don't go anywhere.
I found it.
That's a very nice cooler, David.
It's the sample of the 1918 flu.
- Perfect specimen.
- What? It's impossible.
- Is the RNA intact? - I don't know yet.
But I got this sample out of the permafrost, so I'm expecting minimal degradation.
Wait a minute.
I am on all of the dig list.
I'm hooked into the Norwegians, I get emails from Alexcovich in St.
Petersburg.
I mean it's Where did you get it? Well, I was a little off the radar.
There's no such thing.
They Take months to plan.
There's red tape when you exhume a grave.
I mean what if.
.
What if the media got a? Just be thankful that you never, ever have to do that again.
Because we got it.
Yeah? - Sorry.
I didn't mean to - Oh.
That's okay.
- Have you two met? - We have.
What's up? I.
.
Mayko and I need to speak to you about the trial.
Ah.
.
Okay, um.
.
I'll get out of your way.
Oh, and Jill.
- Sequencing and PCRs ASAP.
- Yes doctor.
And uh Welcome to the lab.
Thank you.
What do you got? So.
.
I did the pathology.
Peroxidase stain showing the cancer cells of the Peterson boy, one hour after treatment.
Two hours.
.
Most of the cancer cells are infected with the virus.
Four hours, the majority of the cancer cells are dead or dying.
Everything is going great and then.
.
Stroke and death.
What went wrong? Okay, so what if the Peterson kid had a hyper response to the virus? You've been talking to Lauren Folley? I looked at her data.
She's not totally out there.
Peterson could have had an allergic reaction to the virus.
Could have caused the swelling that led to the stroke.
Proof.
Where is your proof? Look at the Peterson's cytokine profile in the chip right after injection.
- It's high.
- Could have caused vessel damage.
Could have caused the stroke.
You got a problem with that? Yeah, the Look.
All three kids had high cytokine levels.
One is dead.
The other two are in remission.
Okay, so is it the treatment or the disease that killed the kid? Maybe the kid's brain was set to go.
You know it's not uncommon in an AML patients.
He might've suffered a stroke with or without the treatments.
You're willing to bet lives on that Carlos? The question that we are dealing with here is.
.
If 3,000 kids get this treatment, will 1 die or 1 thousand? There's no way of knowing at this point.
Well, have you tried running a viral-load analysis? Maybe DNA cariotyping the chromosome? Come on, guys.
Get out there.
Be a little creative.
We'll get on it, David.
What? So uh.
.
You gonna find time to get involved with this? Eventually, why? Well, you seem somewhere else.
You know, distracted.
I'm fine, Mom.
New girl? - Mayko, get the fuck out of here.
- Okay, I'm just checking.
Bob.
Excuse me, Bob.
- Yes, Jill.
- Hi.
Um.
.
I need some yellow tips.
- Help yourself.
- Oh great.
Thank you.
Sure Jill.
What is that? Oh that's "L'air du temps".
- This is Clive Christian.
- What? Is that perfume? - Aren't they beautiful? - Yeah.
Oh, this is a classic.
- "Evening in Paris".
- Oo la la.
Yep, perfume is the father of organic chemistry.
It's been around since at least the Babylonians, 4,000 years ago.
Wow.
Yeah, the Egyptians perfected it.
They were the first to use those little fancy perfume bottles, and Greek women and men, both wore perfumes.
No kiddin'.
Yeah, they also used it in sacrifices.
Yeah.
Hi.
Hey, how are you doing? I'm, I'm okay.
How are you? Are you sure you're okay? You sound a little weird.
Yeah.
I'm just on a bus.
I don't want to wake anyone up.
Ah.
.
Where are you? I left you a message.
We're on our way to look for whales.
Yeah, what's that all about? It's just something I have to do.
.
dad.
Don't worry.
How was your trip? Good.
Look dad.
I guess I'll just.
.
I'll call you again to let you know where I am or whatever, okay? Ah.
.
Sure.
Lilith.
I love you dad.
Bye.
I love you dad? Did you know that there were no Chanel Isn't that interesting? Hey Bob.
Go home.
Oh, okay.
Good night.
- Good night, Jill.
- Good night, Bob.
How you doing? My stomach's in a bit of a knot, but I'm gonna finish the first sequence tonight.
Don't you just love the flu.
I bet you say that to all the girls.
- Oh, David.
Is this gonna be weird? - What? Working together.
No.
Absolutely not.
- For you? - No.
No.
It's good.
Still you know What? - I don't know.
Nothing, forget it.
- No no no.
What? What are you gonna say? Well, I mean.
.
Never has to get weird.
If If we uh.
.
You know from time to time.
How is that gonna make it less awkward at work? Well, there won't be any of this pent-up sexual tension between us.
What sexual tension? Look, David.
I'm not the girl who sleeps with the boss.
Oh.
Okay, you're fired.
You want to come over tonight? You're very very bad man.
Oh really.
.
Come on.
I consider us equals.
It's not like It would be an abuse of my power or anything.
I wouldn't treat you any differently then See right there.
That's the problem.
If I'm sleeping with someone I like to be special to him.
You know, I want to be treated better than strangers or colleagues, random.
Excuse me.
- So you understand? - Oh yeah.
Yeah yeah yeah.
Won't mention it again.
And I'll just be up in my office, if you change your mind.
Shit.
No, I appreciate the update from you guys.
Yeah, they're still picking the Miranda apart.
It's a tough one.
They'll figure it out.
Keep me posted on what you find out about Jamieson.
I know you will.
Thanks, Collin.
Bye.
Well, now that we've confirmed his identity MI5's taking the lead on Jamieson.
What have you got? I don't know, might be nothing but I thought that I should throw it into the mix.
Booker's stock portfolio? He's showing a particularly heavy investment in Appliex Pharmaceuticals.
What made you go there? Well, you don't like him, and usually have excellent instinct, so Is it legal to be testing drug from a company you own a big piece of? - Apparently so.
- Interesting.
Keep on it.
Let me know what you find.
No, I appreciate the update from you guys.
Yeah, they're still picking the Miranda part.
This way.
Just here.
- David, this is John Ricci.
- Okay.
Thank you, Dr.
Sandstrom.
- Thank you for seeing me.
- Oh, no problem.
My wife, she asked me to thank you too.
My pleasure.
I'm stil not 100% sure what it is you want.
- The gene therapy.
Is it safe? - Right.
Mr.
Ricci, please have a seat.
And I just need to see you outside for a minute.
We'll just be a moment.
What is going on? David, he's called like 10 times.
He wants to talk to you.
Mr.
Ricci's kid was turned down for the trial because he didn't meet the criteria for the protocol.
.
- It's not my problem.
- Yes, it is.
You're supposed to be making the calls on this trial, instead of doing whatever you've been doing.
I've been working on a little bit more important, alright? Oh, okay.
You've got the father of a very sick boy in there.
He wants to know if you think there's something out there that might save his kid's life.
First he was getting better, doctor.
He was doing okay with the chemo.
The trial protocol only allowed non-responsive chemotherapy patients.
Dr.
Booker was following protocol.
Yeah, sure.
But that was when the trials first started.
Now, Justin, he is ahh.
.
He's not doing so good.
What do they call it? The drug ah - Drug resistance.
- Yeah.
Yeah, that's it.
Justin, he's saturated with that chemo crap.
It don't work no more.
He's dying, doctor.
Dr.
Booker said that that you were gonna make the call.
Yeah.
Well, Dr.
Booker shouldn't have done that.
There's no miracles out there that I can see, Mr.
Ricci.
- That's bullshit? - Oh, no.
- I didn't say that.
- Then what are you saying? You studied the therapy.
- Does it work or doesn't it work? - We're not sure.
Dr.
Sandstrom's going over the data.
- When will you know? - Soon.
Soon.
This is my number at work.
My number at home and the cell number, that's my older boy.
Yeah, you call me when you know, okay? Anytime.
- Day or night.
- I'll call you.
All right.
- My boy, he's not gonna die.
- I'll call you, Mr.
Ricci.
I promise.
I'm looking in your eyes.
And I will hold you to that.
Don't ever do that again.
Got you focused, didn't I? Everything we measured is the same in all the patients.
Karyotype, viral loads, cytokine levels.
There's nothing to show that the treatment triggered the Peterson boy's stroke.
- And nothing to show it didn't.
- Okay, but.
.
Look! It shouldn't be that difficult.
The treatment caused two kids to go into complete remission.
Nobody's saying it didn't.
Look, it's the one death that you're gonna have to deal with.
So here it is.
Make your call.
- Hey.
- Hey.
How did it go? I'm okaying in the trials.
You don't sound so sure about it.
It's the right call.
It's a hell of a way to fight cancer.
- Gloves.
- Oh yeah.
Hey, you got enough phenol solution? You want me to get you more phenol solution? No, that's okay.
Maybe we should hook him up to the robotics, you know.
- It might go faster.
- It moves fast enough.
Sure.
- I have better dexterity.
- Exactly.
Go away, David.
I think I might want to sleep next to them all night.
Wow.
That's a good thing I can work under pressure.
You know, I haven't had a disaster since the thing in '94.
When you uh.
.
took out the entire east wing in the biochem lab? Yeah, you heard about that? David.
Do you know about this? Appliex isn't the only company to have a trial stopped.
Six people died using that arthritis treatments.
Well, it happens Caroline.
I mean, you test the product on 5,000 people, nothing comes up and then you test it on 500,000 people suddenly you got some deaths.
Okay, so what if I told you Booker worked on all three trial phases for the arthritis treatment? Tells me he's got lots of experience.
None of this sends up any red flags? Are you sure you haven't already decided Booker's the bad guy? David.
You're pissing on the wrong tree, Caroline.
I'm gonna put a report on your desk tonight saying the trial should continue.
Oh, okay.
- So Folley was wrong? - No.
I just couldn't prove she was right.
Okay.
- Yes.
- It's Caroline Morrison Oh, oh.
Caroline, hello.
How are you? Good.
I have some news on the leukemia trial.
The senator was asking me about it just this morning.
What do I tell him? We're recommending that the trial resumes.
The treatment's safe? Well, that's what the trial will tell us.
We found no reason not to continue.
Can we get Jim's son into it? I've already enquired.
Oh, I can't thank you enough.
Hello, Mr.
Ricci.
It's ah.
.
David Sandstrom calling.
Yes, sir.
It was my pleasure.
I have some.
.
Well, no no.
It's I'm never too busy to make a phone.
.
Well, I would like to finish, though, sir.
Thank you.
I found nothing to suggest that the treatment caused the death of the Peterson boy.
Yes, that is good news.
However, uh.
.
To be honest with you I found nothing to suggest that it didn't, so What I'm saying is that it's a very experimental treatment, but I am going to recommend that the trial continue.
That is correct, sir.
Well, okay.
You thank.
.
You're welcome.
You're Mr.
Ricci.
Very good, sir.
Yes, thank you, sir.
Goodbye.
Lilith.
Hello? Hello? Shit.
Come on, Lilith.
Hey, it's Lilith.
Leave me a message after the Hey.
What? What the fuck.
What the fuck were you thinking? Do you have any idea what you've done? What kind of shit you're in? Hey hey.
What? Oh shit.
Yeah.
All of it? All eight viral RNA segments, Hemagglutinin, neuraminidase.
Spanish flu.
We got it, David.
- Intact.
- We got it.
We got it.
We got it! Excuse me, excuse me.
I love spanish food.
Especially paella.
Have you ever had David's paella? - No, I haven't.
- Oh.
.
So good.
He told me his secret.
He uses 5 ml.
of curcuma, instead of 2.
5.
- Wow.
- I know.
Shh.
.
So are you flipping out? I'm feeling pretty good.
Do you realize that you've unraveled one of the biggest scientific mysteries of the last 100 years? - Yes, I do.
- Good thing you don't have much of an ego.
It is, isn't it? Now all you have to do is find a vaccine.
Hello.
Joey, how are you? Oh my God What? What? When did you find out? Why didn't you tell me? Well, I would have rather worried than this.
Querido.
Okay, I I'm on the next flight.
No.
I'm, I'm coming.
Lauren, what are you doing here? You didn't listen.
Oh yeah, look I'm sorry the review didn't go your way.
Really, I am.
You know, when I heard that you were doing it.
I thought shit.
Well, at least he's good.
- He'll see.
- Lauren just drink this But you didn't, did you? We went over this in detail.
The trial should continue.
Even though another child is dying? Another patient went into blast crisis after treatment.
Wait wait.
Who're you talking about? He's in a comma, David.
Who? Justin Ricci! That child is dying, because of these fucked up trials! Trials that you said were safe.
You! You signed that boy's death sentence.
You! - Lauren, wait a minute.
- Fuck you, David! Fuck you! Lauren.
Lauren, wait a minute.
Hang on a second! David, would you have refused the chance no matter how small, how remote to save a child's life? Say nothing, nothing happens.
This people, Carlos, they're HIV positive and they never get AIDS.
You can save me.
Your nose is like, bleeding.
Oh shit! No, it's okay.
It happens all the time.
Look, you want to have a good time? Okay, but I don't want to talk about this shit.
Please, Iliana.
Listen to me.
You have an immunity of sorts.
Something I think you can pass along.
- Don't waste my time.
- You could save a man's life.
You could save many lives.
Please.
How are you gonna smuggle a stem cells into the States? You're going to hide them into a tub of butter brickle ice cream? Cut the bullshit, David.
What the fuck is going on here, Carlos?
Where do you find prion samples? In 4 dead people.
These chickens could be carrying a fucking death sentence for millions of people.
What can we do for those who are potentially infected? There is no cure.
Where are you going? Don't you want me to come in with you? Go back to your lab, Dad.
- Lilith, moved in.
- Wow.
- What is she like, 14? - 15.
Tons of attitude! Hira's replacement.
- Are you still interested in Jill Langston? - Absolutely.
What do you want me to do about David? Maybe in Chicago when he's there next week.
Good morning.
It was said of the Spanish Flu, that you felt a little ill at breakfast, went to bed after lunch, and were dead by dinner.
What would you say if I told you I've got a lead on the perfect specimen? Bullshit.
So can I take a couple of days? I'm playing with this guy Archambault, 32.
His heart exploded, David.
Instead of injecting something into him that shouldn't be there, he gets his body to make it.
So Biriliski and Archambault died to avoid a patent infringement? You don't understand.
You can't do it anymore.
You will die.
Fuck you, David.
You're a big shot scientist.
I'm nobody.
How is he? Ah.
.
He's gonna be okay.
He's a tough guy.
And that's about it.
Good.
Ah one more thing.
Yes.
I'm sorry about last week.
I shouldn't have put you on the spot like that.
No.
I admire your integrity.
Even more than I appreciate your keeping Dr.
Sandstrom from going public on this prion thing.
Let's just hope we stop this thing soon enough.
Caroline, I need a personal favor.
A colleague of mine, James Bainbridge, his son Ryan was diagnosed with leukemia about six months ago.
They were admitted into a trial for some new treatment.
I'm not up to speed on it, but they tell me it was incredibly promising.
Was? There is some question about it's safety.
And you'd like NorBAC to get involved? Senator Bainbridge and a lot of sick kids would.
And.
.
Jim would see it as a favor.
And he does sit on a Senate's Science and Tech Committee.
- Garcinia cola.
- That's a plant.
Comes from the same place where ebola lived.
Never heard of it.
A big deal at the International Botanical Congress.
Traditional African medicine.
Poison antidote.
And it works on Zaire Ebola? It works on any strain from what I've read.
It's amazing.
It's a dimeric flamanoid, and if it stops Ebola replication in its tracks You think it's worth throwing at the Miranda Virus? Why not? You got the DNA sequences back from the dental floss yet? Bob should have it this afternoon.
Where is Bob? - He's waiting for us at the hoop.
- Aw, you didn't tell him.
What am I suppose to say, David? Oh Bob, you're too good, you can't play basketball with us? Yes.
Where are you going? Wait.
What meeting? - Left a message on your machine.
- I didn't check it.
Of course.
We've been asked to mediate in the dispute between two researchers in a clinical trial.
- David! - I don't do bureaucratic bullshit.
This bureaucratic bullshit has a US senator attached, who will help give your bank financed and give you every new toy you want.
Who's running the trial? - Julius Booker at the University.
.
- Is this about the new gene therapy treatment for Acute Myeloid Leukemia (AML)? You know about it? I heard they got shutdown, what happened? - One of his test patients died.
- Well, that hurts, but people with leukemia do die.
Why'd they pull the plug? One of his lead researchers, Lauren Folley, claims that.
- Lauren Folley? - You know her? Let me get my coat.
Hello, Robert.
Miss Richmond.
Why don't you get in? All right.
Robert, why don't you come around to the front? All right.
Robert, you're not doing anything wrong.
I feel like I am.
I always have.
Robert, we've had this arrangement for over a year now.
I know I know.
It's just.
.
I don't know what they'll say if they found out.
Well, let's make sure they don't find out.
And the paperwork? Thank you, Robert.
Thank you, Miss Richmond.
Come in.
Dr.
Folick, Caroline Morrison, NorBAC.
Lauren, please.
- Pleased to meet you.
- Nice to meet you.
David.
Long time.
Lauren.
Ahh We were biology undergrads together.
- Back in the dark ages.
- Very dark.
Very dark.
- So I guess we've been invited to the party.
- Yeah.
I'm glad.
I feel like I'm out there all alone.
- Come in.
Sit.
- Thank you.
So, Lauren you think this is a questionable treatment? Not questionable.
Maxwell Peterson was 11 years old.
He was a wonderful, bright boy.
He was diagnosed with leukemia a year ago.
Do you got any proof that the therapy caused the stroke? Well, he died just 4 hours after receiving the treatment.
No, I meant scientific proof.
You know hard numbers, data, that kind of thing.
No.
Not yet.
So you just jumped to the conclusion that the kid died from the injection.
Gene therapy is about injecting a virus.
A good virus.
It goes right into the cancer cells and kills them.
- A "Magic Bullet.
" - I see.
I think that the Peterson boy's system over responded.
Maybe the dosage was wrong - Maybe it was the timing - But you don't know.
.
Neither does Booker.
You brought this up with the internal review board? Yeah, I asked them if they could believe if this was just a coincidence.
Well, did you ask them if it was just a coincidence that the other two patients got better? Look, David.
The point is Booker just wants to plow ahead.
And write this stroke off as a normal occurrence in an AML patient.
Well, he's not wrong.
Is this something that the chief scientist on the project should just ignore? Why would he do that? The university's job is to keep money flowing into research.
And Booker is a money magnet.
Someone's got to do it.
Come on, David.
Cancer treatment is a 20 billion dollar a year business.
If Appliex is the first to market this gene therapy they are going to make a fortune.
Appliex Pharmaceuticals? Yeah.
Wow.
You're butting heads with a hell of a pharmaceutical company.
Yeah, well.
They've had their failures.
Give me a drug medic that hasn't.
Look.
I just think that we need to step back and ask ourselves some hard questions.
I see.
So instead of working with Booker, you just decided to go over his head and blow the whistle on him.
You haven't changed a bit.
I'd say you haven't either.
- My data.
Keep an open mind.
- I will.
- Very nice to meet.
- Nice to meet you.
I wouldn't be surprised if this is her "Best of Celine" collection.
What's the matter with you? I hate Celine Dion.
What's wrong? Folley.
She's so textbook.
She's got no imagination.
She just gets on the tracks one direction.
One conclusion, one answer.
Had been that way since the day I met her.
What? You two had a thing, didn't you? - Where did that come from? - Did you? You know how it is in university, I mean, everybody's sleeping with everybody else.
.
You were sleeping with everybody else? No.
Not everybody.
Oh come one you trying to tell me you didn't sleep around? I don't see that's any of your business.
- Well you're judging me.
- Yeah, just like you're judging Lauren Folley - As a scientist.
A bad scientist.
- Can you be objective? Yes.
- Hey.
- Have you been waiting long or what? No really, no.
So what do you want to do? I don't know.
That.
Looks like fun.
Mick, skaters are losers.
Didn't know that.
So uhh.
.
what's the coolest thing you've ever done? Wow.
That's a huge question.
Like anything.
Like uh.
.
Seen, done or whatever.
Doesn't matter.
I saw a corn-snake eat a mouse.
Like just whole.
Come on you can do better than that.
- Okay, I shaved off all my hair.
- Yeah.
Why? Because I was bored.
I don't know.
Oh I know, a whale.
A whale winked at me.
What do you mean? We went whale watching and we were on the boat and this huge whale, like totally humongous, comes up and it was this far away, I swear, it just came out of the water looked at me and I swear to you, it winked.
It winked at me.
Man.
I want that.
What? I want a whale to wink at me.
- A whale? - Yeah.
- Um.
.
Where are you gonna find a whale? - The ocean.
Whatever, we'll find it.
promising treatment I've ever worked on.
- Is it the safest? - The whole point of the trial is to find out if it's safe, but I can't believe Folley's allegations.
You know we're looking at fast-track designation with the FDA on this? Do you think Folley is way off base here? Well, she's jumping the gun making decisions based on emotions, not science.
Wouldn't be the first time.
A child did die in the trial.
The boy was sick.
He died of a disease that we were trying to save him from.
You see cancer cells, they multiply at an extremely high rate.
We deliver a simple cold virus that makes an RNAi.
RNAi, it's a new method for eliminating proteins like AML-6.
And the RNAi kills the mutant protein in the cell, and cell growth is arrested.
We're tricking them into committing mass suicide.
- Apoptosis.
Wow.
- Exactly.
The RNAl is encoded with an EBV derived plasma under a poll 3 expression.
Now the plasma is targeted to the tumor cells and a viral vector harboring a humanized anti-CD33 binding protein.
Because CD33 is highly expressed in AML cells.
That's it.
See it's a triple barrel approach.
We attack the specific molecular defect in an AML cell, we induce apoptosis and we can even insure higher specificity by using the CD33 binding protein.
It's amazing.
Because of one death, this treatment is going nowhere? See why I'm so Pissed off? Yeah.
I like a man who's not afriad of being a rude, pompous, arrogant, asshole.
That's why we get along so well.
Caroline, what Booker is working on in there is leading edge science.
Folley was one of his senior scientist.
She's over interpreting based on one observation.
Okay, do me a favor.
Explain to me what he was talking about in there? - And don't gloat.
- Okay.
If I had two samples of the same virus, and I put them ideal condition, right? Turn the lights down low, put on a little Barry White - I got it.
- I'd never get a third virus, because viruses don't reproduce that way.
- Thy're asexual.
- Ah you've been doing a little reading eh? Go on.
So in order for a virus to reproduce they've evolved this neat little tricks of breaking into a host cell, killing the boss, taking over, "Okay, you guys are working for me now.
" Pretty soon you got all these nasty little viruses out there and the neighborhood's shot to hell.
Okay.
Okay, so in gene therapy, you take a virus and you alter it, right.
You remove all the nasty bits and replace them with something good.
And now you've got the best delivery system mother nature has to offer.
Because if you inject a few trillion of these nicely altered little viruses into a patient, the viruses will just do what comes naturally, and they will break into - the patient's cell.
.
- And kind of infect them with health? - Pretty amazing, eh? - Yeah.
It is.
Yeah? Hello.
I can barely hear you.
Oh Joe.
Yeah, yeah.
Are you sure? Fucking sure is good enough for me.
I'm on my way.
I'll call you with my details.
On your way where? You know, I gotta.
Here you.
You go ahead.
I'll catch a cab.
- Everything okay? - Oh yeah, yeah, fine.
Fine ahh.
Make sure Carlos gets those and have him start on the evaluation.
- You're not gonna handle this? - What's wrong with Carlos? - Nothing, but.
.
- I love it when you agree.
Where are you going? - Nunavut.
- Nunavut? That's like way up there.
Yeah, permafrost catchy.
And you're doing this why? Because I've been chasing this Spanish Flu ever since I was your age.
Why? Because it killed more people than any other virus known to human kind.
Right, and that's something that excites you.
Yeah! Something that you can't see with the naked eye and wipes out an entire civilization.
It's the bomb man.
Eww So, when are you gonna be back? Ahh I don't know.
Depends on the flight, which depends on the weather.
And this is very important for your trip? I don't know why it got in there.
- You're so weird.
- Okay so, listen.
This is for food, and you know whatever else you might need it for.
You gonna be okay on your own? - I've been my own for half my life.
- Nice.
It's not a slam, it was a reassuring observation.
Ah well, thank you then.
Okay.
I will see you.
I will call you.
If Mick you know, he had a dream too, he should like, totally go for it.
- Absolutely.
- And I should help him.
- Of course.
- Yeah, okay.
- Bye.
- Bye.
Mick, hey hey.
Hey, you ready? Got a magic card.
You drive like a madman.
I didn't see any traffic signs.
Is this it? That's why it took over a year to find it.
Church record said it would be out here somewhere.
I found the dog tags right over here.
This here is your Mr.
George Edward Plane.
In the permafrost since 1918.
What are you doing? It smells good.
Oh.
Bob, I read your report.
No doubt in your mind? Bob! Oh, Good night.
The dental floss DNA, 100% certain it's him? It only takes 10 DNA matches to convict a man to criminal case.
I've given you 20.
Zansinger is Martin Jamieson, the biological father of Daisy Markowitz's baby.
I guess we should be grateful for a terrorist who flosses.
I'm greatful for anyone who flosses.
Um, have we started reviewing the AML trials? David on top of it? We don't know where he is, do we? - He probably does.
- Yeah.
Good night, Bob.
Need some help? No, I'm okay.
What the hell is that? It's his coffin.
Should I be wearing one of those? Oh, no.
Just ah.
.
Stand back a little bit there Joe.
So you done this before? In The old days med students had to find their own corpses, so we're just part of a grand old tradition.
Grave robbing? Oh, you're fucking beautiful.
You are one sick seal.
Polar bears can smell that guy from Come on.
Help me put everything back.
And I mean everything.
So So, now I do some ITPCR and some sequencing to see how degraded the RNA is.
So, how about my money? Oh.
Sorry, man.
And Joe, I tell you, if this works out.
I'm gonna get you ten times this.
I won't hold my breath.
You keep this between ourselves, right? Your dead guy will talk before I will.
Actually, I'm hoping he'll tell us plenty.
Your ride's here, Dav.
Okay.
It was a pleasure doing business with you.
You got any more frozen bodies, you know where to find me.
I got what I need.
So what did you tell your dad? The truth.
You told him the truth and you're still alive? - Yeah.
Well, I left a note.
- Oh, great.
It's not that I'm going to lie.
What I'm doing is not wrong.
Just checking Mick, those are a lot of pills.
Mick, Mick.
Maybe this wasn't a great idea.
I, I.
.
It is.
It is.
Amazing idea.
Okay? Hi honey.
I'm home.
Lilith? Hey dad.
Um.
.
Did you find that virus? Okay now.
Don't freak.
Mick and I went off to look at whales.
So.
.
Okay bye.
It's Lauren.
I wanted to talk to you about the other day.
My cell is 41.
.
Hi David.
Caroline asked me where you were today.
Of course I didn't say anything.
Mainly because I'm not really sure where you are.
If you want to call me and tell me where you are so I can tell Caroline.
, that would be really great.
And I hope you're having a fun time wherever you are.
Hi.
Hi.
- I called.
- Yeah.
I just ah I literally just walked in the door.
Look, ahh, David.
I know that you think of me as that knee jerk grad student and that you don't have a lot of respect.
Do you want to come in? No.
And I want you to know that I'm not the same person that I was back then.
So you're not gonna spend the night? I just.
I ah.
.
I truly believe that Dr.
Booker is making a mistake by not stopping and looking at the data on his gene trial.
Yeah you made that pretty clear the other day.
I want to work with you to make sure that these are safe.
Or.
.
- Sure you don't want to come in for a glass of wine or? - No.
Just look at the data.
And run every test that you can.
You might be saving a life.
- Thanks for listening to me.
- Sure.
- Albert Einstein, right? - Ah.
.
No actually "Mork from Ork".
Oh.
I get those two mixed up all the time.
- Mayko Tran, I'm over in Informatics.
- Jill Langston, virology.
- I know.
Nice to meet you.
- Nice to meet you.
So you had the tour? Pretty awesome, huh? Yeah, it's incredible.
Is that lunch? Sort of.
Rabbit food.
- Come on.
I'll show you where the fridge is.
- Okay.
- So you're hooked up with David in Chicago.
- He interviewed me there, yeah.
Did he behave himself? - I don't know what ask.
.
- It's okay.
That's why we love him.
Hello David.
How is ah.
.
Where were you? Whose shit is this? Oh.
The new virologist.
She's already made herself home.
What new virologist? Oh shit.
- What's wrong? - Nothing.
What's she doing here? - You hired her.
- I did? I'm confused.
Hello David.
This is Jill Langston.
I know.
- She say that MIT, Stanford, Princeton.
.
- Not now Bob.
What are you, ahh? I mean.
Can I ahh - In my office right away.
- Sure.
So no one told you I accepted the offer.
I was out of town.
- I hope it was a pleasant surprise.
- No.
I mean, I mean.
Yes it was.
It It was just.
.
I thought.
- Hi Caroline.
- Hi.
- So you got Jill, eh? - Yeah.
- You're settling in? - Yeah.
Yeah.
Everything's great.
Find an apartment? - I got a lead on a couple.
- Good.
Good.
Jill was one of my early consultants when NorBAC was going through committee.
Really? I didn't want to prejudice you until you two had a chance to meet, but I'm happy it all worked out.
- Yeah.
Here she is.
- Yeah.
So I was just gonna take Jill into my office.
Get her up to speed, that sort of thing.
- Well, you better get right to it.
- Okay.
Ah.
.
Isn't that gonna look a little suspicious? What? Closing the blinds.
What? - You're closing the blinds.
- Yeah.
I do it all the time.
When you have a woman in your office? Yeah.
So.
Is it gonna be okay for you? - Sure hope so.
- Me too.
Oh shit.
Don't go anywhere.
I found it.
That's a very nice cooler, David.
It's the sample of the 1918 flu.
- Perfect specimen.
- What? It's impossible.
- Is the RNA intact? - I don't know yet.
But I got this sample out of the permafrost, so I'm expecting minimal degradation.
Wait a minute.
I am on all of the dig list.
I'm hooked into the Norwegians, I get emails from Alexcovich in St.
Petersburg.
I mean it's Where did you get it? Well, I was a little off the radar.
There's no such thing.
They Take months to plan.
There's red tape when you exhume a grave.
I mean what if.
.
What if the media got a? Just be thankful that you never, ever have to do that again.
Because we got it.
Yeah? - Sorry.
I didn't mean to - Oh.
That's okay.
- Have you two met? - We have.
What's up? I.
.
Mayko and I need to speak to you about the trial.
Ah.
.
Okay, um.
.
I'll get out of your way.
Oh, and Jill.
- Sequencing and PCRs ASAP.
- Yes doctor.
And uh Welcome to the lab.
Thank you.
What do you got? So.
.
I did the pathology.
Peroxidase stain showing the cancer cells of the Peterson boy, one hour after treatment.
Two hours.
.
Most of the cancer cells are infected with the virus.
Four hours, the majority of the cancer cells are dead or dying.
Everything is going great and then.
.
Stroke and death.
What went wrong? Okay, so what if the Peterson kid had a hyper response to the virus? You've been talking to Lauren Folley? I looked at her data.
She's not totally out there.
Peterson could have had an allergic reaction to the virus.
Could have caused the swelling that led to the stroke.
Proof.
Where is your proof? Look at the Peterson's cytokine profile in the chip right after injection.
- It's high.
- Could have caused vessel damage.
Could have caused the stroke.
You got a problem with that? Yeah, the Look.
All three kids had high cytokine levels.
One is dead.
The other two are in remission.
Okay, so is it the treatment or the disease that killed the kid? Maybe the kid's brain was set to go.
You know it's not uncommon in an AML patients.
He might've suffered a stroke with or without the treatments.
You're willing to bet lives on that Carlos? The question that we are dealing with here is.
.
If 3,000 kids get this treatment, will 1 die or 1 thousand? There's no way of knowing at this point.
Well, have you tried running a viral-load analysis? Maybe DNA cariotyping the chromosome? Come on, guys.
Get out there.
Be a little creative.
We'll get on it, David.
What? So uh.
.
You gonna find time to get involved with this? Eventually, why? Well, you seem somewhere else.
You know, distracted.
I'm fine, Mom.
New girl? - Mayko, get the fuck out of here.
- Okay, I'm just checking.
Bob.
Excuse me, Bob.
- Yes, Jill.
- Hi.
Um.
.
I need some yellow tips.
- Help yourself.
- Oh great.
Thank you.
Sure Jill.
What is that? Oh that's "L'air du temps".
- This is Clive Christian.
- What? Is that perfume? - Aren't they beautiful? - Yeah.
Oh, this is a classic.
- "Evening in Paris".
- Oo la la.
Yep, perfume is the father of organic chemistry.
It's been around since at least the Babylonians, 4,000 years ago.
Wow.
Yeah, the Egyptians perfected it.
They were the first to use those little fancy perfume bottles, and Greek women and men, both wore perfumes.
No kiddin'.
Yeah, they also used it in sacrifices.
Yeah.
Hi.
Hey, how are you doing? I'm, I'm okay.
How are you? Are you sure you're okay? You sound a little weird.
Yeah.
I'm just on a bus.
I don't want to wake anyone up.
Ah.
.
Where are you? I left you a message.
We're on our way to look for whales.
Yeah, what's that all about? It's just something I have to do.
.
dad.
Don't worry.
How was your trip? Good.
Look dad.
I guess I'll just.
.
I'll call you again to let you know where I am or whatever, okay? Ah.
.
Sure.
Lilith.
I love you dad.
Bye.
I love you dad? Did you know that there were no Chanel Isn't that interesting? Hey Bob.
Go home.
Oh, okay.
Good night.
- Good night, Jill.
- Good night, Bob.
How you doing? My stomach's in a bit of a knot, but I'm gonna finish the first sequence tonight.
Don't you just love the flu.
I bet you say that to all the girls.
- Oh, David.
Is this gonna be weird? - What? Working together.
No.
Absolutely not.
- For you? - No.
No.
It's good.
Still you know What? - I don't know.
Nothing, forget it.
- No no no.
What? What are you gonna say? Well, I mean.
.
Never has to get weird.
If If we uh.
.
You know from time to time.
How is that gonna make it less awkward at work? Well, there won't be any of this pent-up sexual tension between us.
What sexual tension? Look, David.
I'm not the girl who sleeps with the boss.
Oh.
Okay, you're fired.
You want to come over tonight? You're very very bad man.
Oh really.
.
Come on.
I consider us equals.
It's not like It would be an abuse of my power or anything.
I wouldn't treat you any differently then See right there.
That's the problem.
If I'm sleeping with someone I like to be special to him.
You know, I want to be treated better than strangers or colleagues, random.
Excuse me.
- So you understand? - Oh yeah.
Yeah yeah yeah.
Won't mention it again.
And I'll just be up in my office, if you change your mind.
Shit.
No, I appreciate the update from you guys.
Yeah, they're still picking the Miranda apart.
It's a tough one.
They'll figure it out.
Keep me posted on what you find out about Jamieson.
I know you will.
Thanks, Collin.
Bye.
Well, now that we've confirmed his identity MI5's taking the lead on Jamieson.
What have you got? I don't know, might be nothing but I thought that I should throw it into the mix.
Booker's stock portfolio? He's showing a particularly heavy investment in Appliex Pharmaceuticals.
What made you go there? Well, you don't like him, and usually have excellent instinct, so Is it legal to be testing drug from a company you own a big piece of? - Apparently so.
- Interesting.
Keep on it.
Let me know what you find.
No, I appreciate the update from you guys.
Yeah, they're still picking the Miranda part.
This way.
Just here.
- David, this is John Ricci.
- Okay.
Thank you, Dr.
Sandstrom.
- Thank you for seeing me.
- Oh, no problem.
My wife, she asked me to thank you too.
My pleasure.
I'm stil not 100% sure what it is you want.
- The gene therapy.
Is it safe? - Right.
Mr.
Ricci, please have a seat.
And I just need to see you outside for a minute.
We'll just be a moment.
What is going on? David, he's called like 10 times.
He wants to talk to you.
Mr.
Ricci's kid was turned down for the trial because he didn't meet the criteria for the protocol.
.
- It's not my problem.
- Yes, it is.
You're supposed to be making the calls on this trial, instead of doing whatever you've been doing.
I've been working on a little bit more important, alright? Oh, okay.
You've got the father of a very sick boy in there.
He wants to know if you think there's something out there that might save his kid's life.
First he was getting better, doctor.
He was doing okay with the chemo.
The trial protocol only allowed non-responsive chemotherapy patients.
Dr.
Booker was following protocol.
Yeah, sure.
But that was when the trials first started.
Now, Justin, he is ahh.
.
He's not doing so good.
What do they call it? The drug ah - Drug resistance.
- Yeah.
Yeah, that's it.
Justin, he's saturated with that chemo crap.
It don't work no more.
He's dying, doctor.
Dr.
Booker said that that you were gonna make the call.
Yeah.
Well, Dr.
Booker shouldn't have done that.
There's no miracles out there that I can see, Mr.
Ricci.
- That's bullshit? - Oh, no.
- I didn't say that.
- Then what are you saying? You studied the therapy.
- Does it work or doesn't it work? - We're not sure.
Dr.
Sandstrom's going over the data.
- When will you know? - Soon.
Soon.
This is my number at work.
My number at home and the cell number, that's my older boy.
Yeah, you call me when you know, okay? Anytime.
- Day or night.
- I'll call you.
All right.
- My boy, he's not gonna die.
- I'll call you, Mr.
Ricci.
I promise.
I'm looking in your eyes.
And I will hold you to that.
Don't ever do that again.
Got you focused, didn't I? Everything we measured is the same in all the patients.
Karyotype, viral loads, cytokine levels.
There's nothing to show that the treatment triggered the Peterson boy's stroke.
- And nothing to show it didn't.
- Okay, but.
.
Look! It shouldn't be that difficult.
The treatment caused two kids to go into complete remission.
Nobody's saying it didn't.
Look, it's the one death that you're gonna have to deal with.
So here it is.
Make your call.
- Hey.
- Hey.
How did it go? I'm okaying in the trials.
You don't sound so sure about it.
It's the right call.
It's a hell of a way to fight cancer.
- Gloves.
- Oh yeah.
Hey, you got enough phenol solution? You want me to get you more phenol solution? No, that's okay.
Maybe we should hook him up to the robotics, you know.
- It might go faster.
- It moves fast enough.
Sure.
- I have better dexterity.
- Exactly.
Go away, David.
I think I might want to sleep next to them all night.
Wow.
That's a good thing I can work under pressure.
You know, I haven't had a disaster since the thing in '94.
When you uh.
.
took out the entire east wing in the biochem lab? Yeah, you heard about that? David.
Do you know about this? Appliex isn't the only company to have a trial stopped.
Six people died using that arthritis treatments.
Well, it happens Caroline.
I mean, you test the product on 5,000 people, nothing comes up and then you test it on 500,000 people suddenly you got some deaths.
Okay, so what if I told you Booker worked on all three trial phases for the arthritis treatment? Tells me he's got lots of experience.
None of this sends up any red flags? Are you sure you haven't already decided Booker's the bad guy? David.
You're pissing on the wrong tree, Caroline.
I'm gonna put a report on your desk tonight saying the trial should continue.
Oh, okay.
- So Folley was wrong? - No.
I just couldn't prove she was right.
Okay.
- Yes.
- It's Caroline Morrison Oh, oh.
Caroline, hello.
How are you? Good.
I have some news on the leukemia trial.
The senator was asking me about it just this morning.
What do I tell him? We're recommending that the trial resumes.
The treatment's safe? Well, that's what the trial will tell us.
We found no reason not to continue.
Can we get Jim's son into it? I've already enquired.
Oh, I can't thank you enough.
Hello, Mr.
Ricci.
It's ah.
.
David Sandstrom calling.
Yes, sir.
It was my pleasure.
I have some.
.
Well, no no.
It's I'm never too busy to make a phone.
.
Well, I would like to finish, though, sir.
Thank you.
I found nothing to suggest that the treatment caused the death of the Peterson boy.
Yes, that is good news.
However, uh.
.
To be honest with you I found nothing to suggest that it didn't, so What I'm saying is that it's a very experimental treatment, but I am going to recommend that the trial continue.
That is correct, sir.
Well, okay.
You thank.
.
You're welcome.
You're Mr.
Ricci.
Very good, sir.
Yes, thank you, sir.
Goodbye.
Lilith.
Hello? Hello? Shit.
Come on, Lilith.
Hey, it's Lilith.
Leave me a message after the Hey.
What? What the fuck.
What the fuck were you thinking? Do you have any idea what you've done? What kind of shit you're in? Hey hey.
What? Oh shit.
Yeah.
All of it? All eight viral RNA segments, Hemagglutinin, neuraminidase.
Spanish flu.
We got it, David.
- Intact.
- We got it.
We got it.
We got it! Excuse me, excuse me.
I love spanish food.
Especially paella.
Have you ever had David's paella? - No, I haven't.
- Oh.
.
So good.
He told me his secret.
He uses 5 ml.
of curcuma, instead of 2.
5.
- Wow.
- I know.
Shh.
.
So are you flipping out? I'm feeling pretty good.
Do you realize that you've unraveled one of the biggest scientific mysteries of the last 100 years? - Yes, I do.
- Good thing you don't have much of an ego.
It is, isn't it? Now all you have to do is find a vaccine.
Hello.
Joey, how are you? Oh my God What? What? When did you find out? Why didn't you tell me? Well, I would have rather worried than this.
Querido.
Okay, I I'm on the next flight.
No.
I'm, I'm coming.
Lauren, what are you doing here? You didn't listen.
Oh yeah, look I'm sorry the review didn't go your way.
Really, I am.
You know, when I heard that you were doing it.
I thought shit.
Well, at least he's good.
- He'll see.
- Lauren just drink this But you didn't, did you? We went over this in detail.
The trial should continue.
Even though another child is dying? Another patient went into blast crisis after treatment.
Wait wait.
Who're you talking about? He's in a comma, David.
Who? Justin Ricci! That child is dying, because of these fucked up trials! Trials that you said were safe.
You! You signed that boy's death sentence.
You! - Lauren, wait a minute.
- Fuck you, David! Fuck you! Lauren.
Lauren, wait a minute.
Hang on a second! David, would you have refused the chance no matter how small, how remote to save a child's life? Say nothing, nothing happens.
This people, Carlos, they're HIV positive and they never get AIDS.
You can save me.
Your nose is like, bleeding.
Oh shit! No, it's okay.
It happens all the time.
Look, you want to have a good time? Okay, but I don't want to talk about this shit.
Please, Iliana.
Listen to me.
You have an immunity of sorts.
Something I think you can pass along.
- Don't waste my time.
- You could save a man's life.
You could save many lives.
Please.
How are you gonna smuggle a stem cells into the States? You're going to hide them into a tub of butter brickle ice cream? Cut the bullshit, David.
What the fuck is going on here, Carlos?